Mechanism of Processing Semen Crotonis Pulveratum Based on Network Pharmacology

SHANG Jinfeng; LI Qiannan; CUI Yiran; LIU Xin

doi:10.14009/j.issn.1672-2124.2022.08.007

您当前的位置：

首页 >

文章列表页 >

Mechanism of Processing Semen Crotonis Pulveratum Based on Network Pharmacology

更新时间：2023-04-16

- Mechanism of Processing Semen Crotonis Pulveratum Based on Network Pharmacology
- Vol. 22, Issue 8, Pages: 923-930(2022)
- 作者机构：
  
  1. 北京中医药大学中药学院
  2. 首都医科大学附属北京中医医院药学部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.08.007
  CLC： R285
- Published：2022，
扫描看全文
SHANG Jinfeng, LI Qiannan, CUI Yiran, et al. Mechanism of Processing Semen Crotonis Pulveratum Based on Network Pharmacology. [J]. 22(8):923-930(2022)
DOI：

SHANG Jinfeng, LI Qiannan, CUI Yiran, et al. Mechanism of Processing Semen Crotonis Pulveratum Based on Network Pharmacology. [J]. 22(8):923-930(2022) DOI： 10.14009/j.issn.1672-2124.2022.08.007.

摘要

目的：运用网络药理学方法探讨巴豆制霜增效减毒的机制。方法：通过中医药整合药理学研究平台V2.0获取并筛选巴豆、巴豆霜的成分和靶点，采用admetSAR-2.0获取巴豆主要成分的药动学和毒理学参数。将巴豆、巴豆霜共有靶点和巴豆特有靶点通过STRING 11.0数据库构建蛋白质-蛋白质相互作用网络，采用DAVID进行京都基因与基因组百科全书通路富集分析，利用Cytoscape 3.8.0构建成分-靶点-通路网络，并进行网络拓扑分析。结果：经分析得到巴豆、巴豆霜共有成分6个和靶点202个，巴豆特有成分31个和靶点107个。巴豆、巴豆霜共有成分均能透过血脑屏障并被人体小肠吸收。巴豆发挥药效涉及尼古丁成瘾、GABA能突触和Rap1信号通路等通路。巴豆表现毒性涉及脂肪酸代谢通路、PPAR信号通路等。巴豆制霜机制可能与苯丙胺成瘾和长时程增强等神经系统通路相关。结论：巴豆制霜具有增效减毒作用，与多个靶点和通路相关，探讨靶点和通路有助于阐释巴豆制霜机制。

Abstract

OBJECTIVE: To probe into the mechanism of synergistic effect and toxicity reduction of processing semen crotonis pulveratum by using network pharmacology. METHODS: The components and targets of croton and semen crotonis pulveratum were obtained and screened by integrative pharmacology-based research platform of traditional Chinese medicine（TCMIP） V2.0. Pharmacokinetic and toxicological parameters of Croton were obtained by admetSAR-2.0. Protein-protein interaction network of common targets of croton and semen crotonis pulveratum

and specific targets of croton was constructed by STRING 11.0. Kyoto encyclopedia of genes and genomes（KEGG） enrichment analysis were performed by DAVID. Cytoscape 3.8.0 was used to construct the component-target-pathway network and perform network topology analysis. RESULTS: There were 6 common components and 202 common targets in croton and semen crotonis pulveratum. There were 31 specific components and 107 specific targets in croton. The common components of croton and semen crotonis pulveratum could pass through the blood brain barrier and be absorbed by human small intestine. The pharmacodynamics of croton involved nicotine addiction

GABAergic synapse and Rap1 signaling pathway. The toxicity of croton involved fatty acid metabolism and PPAR signaling pathway. The mechanism of processing semen crotonis pulveratum may be related to nervous system pathways such as amphetamine addiction and long-term potentiation. CONCLUSIONS: Processing semen crotonis pulveratum has synergistic effect and toxicity reduction

which is related to multiple targets and pathways. To explore the predicted targets and pathways is helpful to explain the mechanism of processing semen crotonis pulveratum.

关键词

药效毒性网络药理学巴豆制霜机制

Keywords

PharmacodynamicsToxicityNetwork pharmacologyProcessing semen crotonis pulveratumMechanism

references

查看原文

Views

108

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Mechanism of Huazhi Rougan Granules in the Treatment of Non-Alcoholic Fatty Liver Disease Based on Network Pharmacology and Molecular Docking

Mechanism of Guizhi Shaoyao Zhimu Decoction in the Treatment of Rheumatoid Arthritis-Interstitial Lung Disease Based on Network Pharmacology and Molecular Docking Technology

Mechanism of Danggui Shaoyao Powder in the Treatment of Primary Dysmenorrhea Based on the Network Pharmacology and Molecular Docking

Mechanism of Shenfu Injection in the Treatment of Hemorrhagic Shock Based on Network Pharmacology and Molecular Docking Technology

Mechanism of Mailuo Shutong Pills in the Treatment of Hemorrhoids Based on Network Pharmacology

Related Author

LIU Yingying

ZHANG Jingyuan

TAN Yingying

WANG Haojia

WU Chao

FAN Xiaotian

LI Jialin

CHEN Meilin

Related Institution

Dept. of Respiratory, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University

College of the 1st Clinical Medical Sciences, Henan University of Chinese Medicine

Dept.of Gynaecology and Obstetrics, the First Affiliated Hospital of Henan University of Chinese Medicine

Dept.of Gynecology, the First Affiliated Hospital of Guangzhou University of Chinese Medicine

Dept.of Emergency, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University

⁰