Pharmacodynamic Analysis of Levetiracetam in the Treatment of Epilepsy in Children

WANG Yinghui; WANG Li; WU Ye; WEI Minji; LU Wei; LI Xingang

doi:10.14009/j.issn.1672-2124.2022.08.006

您当前的位置：

首页 >

文章列表页 >

Pharmacodynamic Analysis of Levetiracetam in the Treatment of Epilepsy in Children

更新时间：2023-04-16

- Pharmacodynamic Analysis of Levetiracetam in the Treatment of Epilepsy in Children
- Vol. 22, Issue 8, Pages: 920-922(2022)
- 作者机构：
  
  1. 首都医科大学附属北京友谊医院儿科
  2. 北京大学第一医院儿科
  3. 北京大学药学院
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.08.006
  CLC： R742.1
- Published：2022，
扫描看全文
WANG Yinghui, WANG Li, WU Ye, et al. Pharmacodynamic Analysis of Levetiracetam in the Treatment of Epilepsy in Children. [J]. 22(8):920-922(2022)
DOI：

WANG Yinghui, WANG Li, WU Ye, et al. Pharmacodynamic Analysis of Levetiracetam in the Treatment of Epilepsy in Children. [J]. 22(8):920-922(2022) DOI： 10.14009/j.issn.1672-2124.2022.08.006.

摘要

目的：探讨左乙拉西坦用于儿童癫痫的药效、血药浓度与剂量的关系，为左乙拉西坦的儿童用药提供一定的参考。方法：采用NONMEN软件和Oracle crystal ball软件，对左乙拉西坦血药浓度和癫痫发作频率进行分析。结果：NONMEM软件分析结果显示，随着左乙拉西坦血药浓度的增加，疗效趋于变好；癫痫控制概率为50%时，对应的血药浓度为24μg/mL;当血药浓度达到36μg/mL时，癫痫控制概率升高不明显。Oracle crystal ball软件分析结果显示，左乙拉西坦治疗儿童癫痫的最佳用药剂量为20～48 mg/(kg·d)。结论：左乙拉西坦的血药浓度与疗效具有一定的相关性，但不是药物浓度越高，疗效越好，治疗儿童癫痫需要个体化用药。

Abstract

OBJECTIVE: To probe into the correlation between efficacy

blood concentration and dose of levetiracetam in the treatment of children with epilepsy

so as to provide a certain reference for the medication of levetiracetam in children. METHODS: Levetiracetam blood concentration and epilepsy frequency were analyzed by NONMEN software and oracle crystal ball software. RESULTS: NONMEM software analysis showed that the efficacy tended to become better as the levetiracetam blood concentration increased. When the epilepsy control rate was 50%

the corresponding blood concentration was 24 μg/mL. When the blood concentration reached 36 μg/mL

the increase of epilepsy control rate was not significant. Analysis results of oracle crystal ball software showed that the optimal dosage of levetiracetam in the treatment of children with epilepsy was from 20 mg/（kg·d） to 48 mg/（kg·d）. CONCLUSIONS: The blood concentration of levetiracetam has a certain correlation with the efficacy

but it is not that the higher the drug concentration

the better the efficacy. The treatment of epilepsy in children requires individualized medication.

关键词

左乙拉西坦血药浓度剂量疗效

Keywords

LevetiracetamBlood concentrationDoseEfficacy

references

查看原文

Views

111

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Blood Trough Concentration Monitoring and Efficacy of Vancomycin in the Treatment of Methicillin-Resistant Staphylococcus aureus Infection

Efficacy of Huaiqihuang Granules in the Adjuvant Treatment of Lupus Nephritis and Its Effects on Serum Ferritin

Prognosis and Safety of Programmed Death 1 Inhibitors in First-Line Treatment of Advanced Non-Small Cell Lung Cancer

Efficacy and Safety of Apatinib Mesylate Combined with Etoposide in the Treatment of Platinum-Resistant Recurrent Ovarian Cancer

Meta-Analysis of Efficacy of PD-1/PD-L1 Monoclonal Antibody in Gastric Cancer or Adenocarcinoma of the Gastroesophageal Junction

Related Author

LIU Yunning

LI Xiaofeng

TANG Jianhua

JIANG Aiwen

CHU Mingjuan

ZHANG Heming

WANG Jie

LI Yuan

Related Institution

Dept.of Pharmacy, the First Affiliated Hospital of Hebei North University

Dept.of Microbiology, the First Affiliated Hospital of Hebei North University

Dept.of Integrated Chinese and Western Medicine, Liyuan Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology

Dept. of Oncology, Huangshan People’s Hospital

Dept. of Gynaecology and Obstetrics,the Sixth Medical Center of PLA General Hospital

⁰