Progress of Safety of Roxadustat in the Treatment of Renal Anemia

doi:10.14009/j.issn.1672-2124.2022.06.028

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Progress of Safety of Roxadustat in the Treatment of Renal Anemia

更新时间：2022-10-08

- Progress of Safety of Roxadustat in the Treatment of Renal Anemia
- Vol. 22, Issue 6, Pages: 761-764(2022)
- 作者机构：
  
  1. 中国人民解放军第305医院药局
  2. 北京医院药学部国家老年医学中心中国医学科学院老年医学研究院北京市药物临床风险与个体化应用评价重点实验室(北京医院)
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.06.028
  CLC： R692
- Published：2022，
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Progress of Safety of Roxadustat in the Treatment of Renal Anemia. [J]. 22(6):761-764(2022)
DOI：

Progress of Safety of Roxadustat in the Treatment of Renal Anemia. [J]. 22(6):761-764(2022) DOI： 10.14009/j.issn.1672-2124.2022.06.028.

摘要

针对罗沙司他治疗肾性贫血的安全性问题，检索相关国内外文献，从作用机制、药动学、药效学和国内外用药安全性研究等方面进行分析。发现罗沙司他在发挥升高血红蛋白作用的同时，可能引发心血管事件、血管通路血栓形成、深静脉血栓形成、癫痫发作和严重感染等不良反应，与安慰剂或对照药相比，其存在安全性风险升高的趋势。表明罗沙司他可有效改善患者的肾性贫血症状，但仍需重点关注其引发的安全性问题。

Abstract

In view of the safety of roxadustat in the treatment of renal anemia

relevant domestic and foreign literature were searched and analyzed from the aspects of mechanism of action

pharmacokinetics

pharmacodynamics and drug safety research at home and abroad. It is found that while increasing hemoglobin

roxadustat may cause adverse drug reactions such as cardiovascular events

vascular access thrombosis

deep vein thrombosis

seizures and severe infections

and there is a tendency of higher safety risk compared with placebo or control drugs. It is suggested that roxadustat can effectively improve the symptoms of renal anemia in patients

yet the safety of roxadustat should be paid more attention.

关键词

罗沙司他肾性贫血安全性不良反应

Keywords

RoxadustatRenal anemiaSafetyAdverse reaction

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