OBJECTIVE: To probe into the characteristics of drug-related problems（DRP） in postoperative analgesia treatment of orthopaedic patients

so as to provide basis for pharmacists to intervene postoperative analgesia treatment and promote the rational use of analgesics. METHODS: Medical orders of postoperative patients in orthopaedics of the hospital from Apr. to Jun. 2021 were collected. Retrospective review of postoperative analgesic drugs was carried out by pre-prescription review system combined with manual review. DRP were summarized and analyzed by using the Pharmaceutical Care Network Europe（PCNE） classification system. RESULTS: A total of 272 patients with orthopaedic surgery were enrolled

of which 186 DRP were found in 124 patients（45.59%）. The main problem types of DRP were possible adverse drug events（90 cases

48.39%） and poor treatment effect（76 cases

40.86%）. The main causes of DRP were interaction（35 cases

18.82%）

long course of treatment（35 cases

18.82%）

repeated drug use（28 cases

15.05%） and improper drug selection（27 cases

14.52%）. CONCLUSIONS: There are still many DRP in postoperative analgesia treatment of orthopaedic patients. Pharmacists can effectively find problems and analyze causes by using PCNE classification system

which provides basis for standardized clinical rational drug use

and helps to improve postoperative pain and accelerate postoperative recovery.