Chaimu Xingnao Decoction Combined with Western Medicine in the Treatment of Brain Tissue Injury and Cognitive Disorders After Stroke: Meta-Analysis and Trial Sequential Analysis

WANG Haikun; WU Na; LI Cunming; LIN Ziwei

doi:10.14009/j.issn.1672-2124.2022.06.023

您当前的位置：

首页 >

文章列表页 >

Chaimu Xingnao Decoction Combined with Western Medicine in the Treatment of Brain Tissue Injury and Cognitive Disorders After Stroke: Meta-Analysis and Trial Sequential Analysis

更新时间：2022-10-08

- Chaimu Xingnao Decoction Combined with Western Medicine in the Treatment of Brain Tissue Injury and Cognitive Disorders After Stroke: Meta-Analysis and Trial Sequential Analysis
- Vol. 22, Issue 6, Pages: 738-743(2022)
- 作者机构：
  
  1. 安徽理工大学附属亳州医院/亳州市人民医院药学部
  2. 安徽理工大学附属亳州医院/亳州市人民医院中医科
  3. 安徽理工大学附属亳州医院/亳州市人民医院全科医学科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.06.023
  CLC： R743.3
- Published：2022，
扫描看全文
WANG Haikun, WU Na, LI Cunming, et al. Chaimu Xingnao Decoction Combined with Western Medicine in the Treatment of Brain Tissue Injury and Cognitive Disorders After Stroke: Meta-Analysis and Trial Sequential Analysis. [J]. 22(6):738-743(2022)
DOI：

WANG Haikun, WU Na, LI Cunming, et al. Chaimu Xingnao Decoction Combined with Western Medicine in the Treatment of Brain Tissue Injury and Cognitive Disorders After Stroke: Meta-Analysis and Trial Sequential Analysis. [J]. 22(6):738-743(2022) DOI： 10.14009/j.issn.1672-2124.2022.06.023.

摘要

目的：运用Meta分析方法，探讨柴牡醒脑汤联合西医治疗脑卒中后脑组织损伤和认知功能障碍的有效性。方法：计算机检索the Cochrane Library、PubMed、Embase、中国知网、中国生物医学文献数据库、万方数据库和维普数据库，搜集相关随机对照试验(RCT)

检索时限为建库至2021年2月。筛选文献并提取资料后，应用RevMan 5.4软件进行Meta分析，并使用TSA v0.9软件进行试验序贯分析(TSA)。结果：共纳入9篇RCT文献，包括777例患者。Meta分析结果显示，与常规西医治疗相比，柴牡醒脑汤联合西医治疗可提高总有效率(RR=1.25

95%CI=1.17～1.34

P<0.000 01)、神经行为认知状况测试评分(RR=6.36

95%CI=5.08～7.63

P<0.000 01)

降低血液流变学指标水平(全血高切黏度：RR=-0.53

95%CI=-0.58～-0.49

P<0.000 01;全血低切黏度：RR=-2.03

95%CI=-2.56～-1.50

P<0.000 01;血浆黏度：RR=-0.21

95%CI=-0.24～-0.18

P<0.000 01)

提高血管增生相关指标水平(血管内皮生长因子：RR=57.50

95%CI=51.33～63.66

P<0.000 01;血管生成素-1:RR=6.58

95%CI=6.00～7.16

P<0.000 01)

差异均有统计学意义。TSA结果显示，柴牡醒脑汤联合西医治疗提高总有效率的证据可靠。结论：现有研究结果表明，柴牡醒脑汤联合西医治疗脑卒中后脑组织损伤和认知功能障碍的临床疗效较好，但该结论尚需更多高质量RCT进行验证。

Abstract

OBJECTIVE: To evaluate the effectiveness of Chaimu Xingnao decoction combined with western medicine in the treatment of brain tissue injury and cognitive disorders after stroke by Meta-analysis. METHODS: The Cochrane Library、PubMed、Embase、CNKI、CBM、Wanfang Data and VIP were electronically retrieved to collect the relevant randomized controlled trials（RCT）. The retrieval time was from the establishment of the database to Feb. 2021. After literature screening and data extraction

Meta-analysis was performed by RevMan 5.4 software and trial sequential analysis（TSA） was performed by TSA v0.9 software. RESULTS: A total of 9 RCT were extracted

including 777 patients. Compared with conventional western medicine treatment

Chaimu Xingnao decoction combined with western medicine could improve the total effective rate（RR=1.25

95%CI=1.17-1.34

P<0.000 01）

neurobehavioral cognitive status examination score（RR=6.36

95%CI=5.08-7.63

P<0.000 01）

decreased the level of hemorheology indicators（whole blood high shear viscosity: RR=-0.53

95%CI=-0.58--0.49

P<0.000 01; whole blood low shear viscosity: RR=-2.03

95%CI=-2.56--1.50

P<0.000 01; plasma viscosity: RR=-0.21

95%CI=-0.24--0.18

P<0.000 01）

and increased the levels of vascular proliferation related indicators（vascular endothelial growth factor: RR=57.50

95%CI=51.33-63.66

P<0.000 01; angiopoietin-1: RR=6.58

95%CI=6.00-7.16

P<0.000 01）

the differences were statistically significant. TSA results showed that Chaimu Xingnao decoction combined with western medicine can improve the total effective rate of treatment. CONCLUSIONS: Results of the available studies suggest that the clinical efficacy of Chaimu Xingnao decoction in the treatment of brain tissue injury and cognitive disorders after stroke is significant

yet more high-quality RCT are needed to validate the conclusions.

关键词

柴牡醒脑汤脑卒中脑组织损伤认知功能障碍Meta分析

Keywords

Chaimu Xingnao decoctionStrokeBrain tissue injuryCognitive disordersMeta-analysis

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Systematic Review of Huisheng Oral Liquid on Coagulation Function, Efficacy and Safety of Patients with Non-Small Cell Lung Cancer

Systematic Review of Efficacy and Safety of Dantian Jiangzhi Pills Combined with Statins in the Treatment of Hyperlipidemia

Systematic Review of Clinical Efficacy and Safety of Formula Granules of Liangfu Pill in the Treatment of Epigastric Pain

Systematic Review of Runzao Zhiyang Capsules Combined with Antihistamine in the Treatment of Chronic Urticaria

Meta-Analysis of Efficacy and Safety of Ticagrelor Combined with Rosuvastatin Therapy in the Treatment of Unstable Angina Pectoris

Related Author

ZHANG Jinhua

TIAN Yuan

YANG Xiaoping

ZHANG Yi

LIU Wei

LI Xingxing

FAN Zongjing

CUI Jie

Related Institution

Dept. of Oncology, Jingmen First People’s Hospital

Traditional Chinese Medicine Phenomics Research Center, Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University

Dept. of Internal Medicine of Traditional Chinese Medicine, Shanghai Seventh People’s Hospital

Dept. of Internal Medicine of Traditional Chinese Medicine, Shanghai Tongren Hospital

Second School of Clinical Medicine, Beijing University of Chinese Medicine

⁰