Effects of Xuebijing Injection on Myocardial Injury Markers and Inflammatory Indicators in Patients with Sepsis Complicated with Myocardial Injury

HAN Ning; CUI Xiaozheng

doi:10.14009/j.issn.1672-2124.2022.06.019

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Effects of Xuebijing Injection on Myocardial Injury Markers and Inflammatory Indicators in Patients with Sepsis Complicated with Myocardial Injury

更新时间：2022-10-08

- Effects of Xuebijing Injection on Myocardial Injury Markers and Inflammatory Indicators in Patients with Sepsis Complicated with Myocardial Injury
- Vol. 22, Issue 6, Pages: 719-721(2022)
- 作者机构：
  
  1. 北京市昌平区中西医结合医院重症医学科
  2. 清华大学附属北京清华长庚医院心脏外科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.06.019
  CLC： R542.22;R459.7
- Published：2022，
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HAN Ning, CUI Xiaozheng. Effects of Xuebijing Injection on Myocardial Injury Markers and Inflammatory Indicators in Patients with Sepsis Complicated with Myocardial Injury. [J]. 22(6):719-721(2022)
DOI：

HAN Ning, CUI Xiaozheng. Effects of Xuebijing Injection on Myocardial Injury Markers and Inflammatory Indicators in Patients with Sepsis Complicated with Myocardial Injury. [J]. 22(6):719-721(2022) DOI： 10.14009/j.issn.1672-2124.2022.06.019.

摘要

目的：探讨血必净注射液对并发心肌损伤的脓毒症患者心肌损伤标志物和炎症指标的影响。方法：采用回顾性分析法，选取2018年6月至2021年10月北京市昌平区中西医结合医院重症医学科收治的并发心肌损伤的脓毒症患者36例作为研究对象，按照治疗方法的不同分为对照组和观察组，每组18例。对照组患者进行西医常规治疗，观察组患者在对照组治疗的基础上联合应用血必净注射液，对比两组患者心肌损伤标志物[肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)]、N末端脑钠肽前体(NT-proBNP)和炎症指标[降钙素原(PCT)、C反应蛋白(CRP)和白细胞计数(WBC)]改善情况的差异。结果：经过10 d的治疗，观察组患者各项观察指标的改善情况优于对照组。(1)观察组患者治疗后的心肌损伤标志物(cTnI、CK-MB)及NT-proBNP水平低于对照组，差异均有统计学意义(P<0.05);(2)观察组患者治疗后的炎症指标(PCT、CRP和WBC)水平低于对照组，差异有统计学意义(P<0.05)。结论：血必净注射液对于脓毒症并发心肌损伤的患者，有利于改善其心肌损伤标志物水平，降低其炎症指标水平。

Abstract

OBJECTIVE: To probe into the effects of Xuebijing injection on myocardial injury markers and inflammatory indicators in patients with sepsis complicated with myocardial injury. METHODS: By retrospective analysis

36 patients with sepsis complicated with myocardial injury admitted into the department of intensive care medicine in Beijing Changping District Integrated Chinese and Western Medicine Hospital from Jun. 2018 to Oct. 2021 were extract to be divided into the control group and the control group according to different treatment methods

with 18 cases in each group. The control group was treated with conventional western medicine

while the observation group received Xuebijing injection on the basis of the control group. The improvement of myocardial injury markers [troponin I（cTnI）

creatine kinase isoenzyme（CK-MB）]

N-terminal pro-brain natriuretic peptide（NT-proBNP） and inflammatory indicators [procalcitonin（PCT）

C-reactive protein（CRP） and white blood cell count（WBC）] were compared between two groups. RESULTS: After treatment of 10 d

the improvement of indicators in the observation group was better than that in the control group.（1） The levels of myocardial injury markers（cTnI

CK-MB） and NT-proBNP in the observation group after treatment were lower than those in the control group

the differences were statistically significant（P<0.05）.（2） The levels of inflammatory indicators（PCT

CRP and WBC） in the observation group after treatment were lower than those in the control group

with statistically significant differences（P<0.05）. CONCLUSIONS: Xuebijing injection is beneficial to improve the levels of myocardial injury markers and reduce the levels of inflammatory indicators in patients with sepsis complicated with myocardial injury.

关键词

血必净注射液心肌损伤脓毒症心肌损伤标志物N末端脑钠肽前体炎症指标

Keywords

Xuebijing injectionMyocardial injurySepsisMyocardial injury markersN-terminal pro-brain natriuretic peptideInflammatory indicators

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