OBJECTIVE: To probe into the effects of Zhikang capsules on wound healing and expression of serum epidermal growth factor（EGF）

fibronectin（FN） after anal fistula surgery. METHODS: A total of 120 cases of postoperative anal fistula patients admitted into the proctology department of the hospital from Mar. 2019 to Jul. 2020 were extracted to be divided into the control group（n=60） and the observation group（n=60） via the random number table. On the basis of routine treatment

the control group was given fumigation of potassium permanganate

while the observation group received Zhikang capsules on the basis of the control group

and the curative effect was evaluated after 14 days of treatment. The effusion

edema

granulation morphology

healing rate and healing time of two groups were compared. The expression levels of EGF and FN were detected before and after treatment. Adverse drug reactions during treatment were recorded in two groups. RESULTS: The total effective rate in the observation group was 93.33%（56/60）

significantly higher than 76.67%（46/60） in the control group

the difference was statistically significant（P<0.05）. From the 7 th day after treatment

the scores of effusion and edema in the control group were significantly lower than those before treatment; from the 3 th day after treatment

the scores of effusion and edema in the observation group were significantly lower than those before treatment; at 3

7 and 14 days after treatment

the scores of effusion and edema in the observation group were lower than those in the control group

with statistically significant difference（P<0.05）. From the 3 th day after treatment

the wound granulation morphology scores of two groups were significantly lower than those before treatment

and the wound granulation morphology scores of the observation group were significantly lower than those of the control group at the same time point

with statistically significant difference（P<0.05）. Compared with the control group

the wound healing rate was higher and the healing time was shorter in the observation group

with statistically significant difference（P<0.05）. After 14 days of treatment

the expression levels of EGF and FN in two groups were significantly higher than before treatment; compared with the control group

the expression levels of EGF and FN in the observation group increased significantly

with statistically significant difference（P<0.05）. There were no obvious adverse drug reactions in two groups during treatment. CONCLUSIONS: The efficacy of Zhikang capsules is definite and reliable

which can significantly increase the expression of EGF and FN in patients

and improve the wound healing after anal fistula surgery.