Effects of Osteoking on Bone Metabolism and Bone Mineral Density After Surgery of Osteoporotic Vertebral Compression Fractures

HAO Ming; LIU Xiaohui; YAO Xiaowei; PAN Shuo; CAO Ran; CAO Jianhui

doi:10.14009/j.issn.1672-2124.2022.06.007

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Effects of Osteoking on Bone Metabolism and Bone Mineral Density After Surgery of Osteoporotic Vertebral Compression Fractures

更新时间：2022-10-08

- Effects of Osteoking on Bone Metabolism and Bone Mineral Density After Surgery of Osteoporotic Vertebral Compression Fractures
- Vol. 22, Issue 6, Pages: 664-667(2022)
- 作者机构：
  
  石家庄市人民医院骨一科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.06.007
  CLC： R687.3
- Published：2022，
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HAO Ming, LIU Xiaohui, YAO Xiaowei, et al. Effects of Osteoking on Bone Metabolism and Bone Mineral Density After Surgery of Osteoporotic Vertebral Compression Fractures. [J]. 22(6):664-667(2022)
DOI：

HAO Ming, LIU Xiaohui, YAO Xiaowei, et al. Effects of Osteoking on Bone Metabolism and Bone Mineral Density After Surgery of Osteoporotic Vertebral Compression Fractures. [J]. 22(6):664-667(2022) DOI： 10.14009/j.issn.1672-2124.2022.06.007.

摘要

目的：探讨恒古骨伤愈合剂在骨质疏松性椎体压缩性骨折（OVCF）经皮椎体成形术/经皮椎体后凸成形术（PKP）后的应用价值，以及其对患者骨代谢情况、骨密度水平的影响。方法：选择2019年6月至2020年6月该院择期行PKP术的OVCF患者66例，采用随机数表法分为对照组和观察组，每组33例。对照组患者术后采用标准抗骨质疏松治疗方案，观察组患者在对照组的基础上加用恒古骨伤愈合剂，治疗观察12周。比较两组患者的疗效、术后骨折愈合时间，并观察患者治疗前后骨代谢指标、骨密度变化，随访观察患者的新发骨折情况。结果：观察组患者的治疗总有效率为100.00%

较对照组的87.88%（29/33）明显更高；观察组患者术后骨折愈合时间短于对照组，上述差异均有统计学意义（P

0.05）。两组患者治疗后血清碱性磷酸酶（ALP）、骨钙素（BGP）水平较治疗前升高，而尿-抗酒石酸酸性磷酸酶（U-TRAP）、尿钙/肌酐(U-Ca

/Cr)和尿羟脯氨酸/肌酐（U-HYP/Cr）水平较治疗前降低；且观察组患者治疗后的ALP、BGP水平高于对照组，U-TRAP、U-Ca

/Cr和U-HYP/Cr水平低于对照组，上述差异均有统计学意义（P

0.05）。两组患者治疗后的腰椎L

2—4

、股骨颈骨密度均较治疗前升高，且观察组患者治疗后的腰椎L

2—4

、股骨颈骨密度高于对照组，差异均有统计学意义（P

0.05）。观察组患者新发骨折率为3.03%（1/33）

较对照组的18.18%（6/33）明显更低，差异有统计学意义（P

0.05）。结论：恒古骨伤愈合剂能够显著促进OVCF术后患者的骨形成，抑制骨吸收，增加骨密度，对于促进骨折早日愈合和预防椎体再发骨折具有积极的意义。

Abstract

OBJECTIVE: To probe into the application value of osteoking after percutaneous vertebroplasty/percutaneous kyphoplasty（PKP） for osteoporotic vertebral compression fracture（OVCF）

and its effects on bone metabolism and bone mineral density of patients. METHODS: A total of 66 patients with OVCF undergoing PKP surgery in our hospital from Jun. 2019 to Jun. 2020 were extracted to be divided into the control group and the observation group via the random number table

with 33 cases in each group. The control group was treated with standard anti-osteoporosis scheme after surgery

while the observation group received osteoking on the basis of the control group

both groups were treated for 12 weeks. The efficacy

time of fracture healing were compared between two groups. Changes of bone metabolism and bone mineral density were observed before and after treatment

and the new fractures were followed up. RESULTS: The total effective rate of the observation group was 100.00%

higher than that of the control group（87.88%

29/33）

and the time of fracture healing of the observation group was shorter than that of the control group

with statistically significant differences（P

0.05）. After treatment

the levels of serum alkaline phosphatase（ALP） and osteocalcin（BGP） in both groups increased compared with before treatment

while the urinary tartrate-resistant acid phosphatase（U-TRAP）

urinary calcium/creatinine(U-Ca

/Cr) and urinary hydroxyproline/creatinine（U-HYP/Cr） decreased compared with before treatment; after treatment

the levels of ALP and BGP in the observation group were higher than those in the control group

while U-Trap

U-Ca

/Cr and U-HYP/Cr in the observation group were lower than those in the control group

the differences were statistically significant（P

0.05）. After treatment

the bone mineral density of lumbar spine L

2—4

and femoral neck of two groups increased compared with before treatment

and the bone mineral density of lumbar spine L

2—4

and femoral neck of the observation group was higher than that of the control group

the differences were statistically significant（P

0.05）. The rate of new fracture in the observation group was 3.03%（1/33）

significantly lower than 18.18%（6/33） in the control group

with statistically significant differences（P

0.05）. CONCLUSIONS: Osteoking can significantly promote the bone formation

inhibit the bone resorption and enhance the bone mineral density in patients with OVCF

which is of positive significance to promote early fracture healing and prevent recurrent vertebral fractures.

关键词

骨质疏松性椎体压缩性骨折恒古骨伤愈合剂骨代谢骨密度

Keywords

Osteoporotic vertebral compression fractureOsteokingBone metabolismBone mineral density

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