OBJECTIVE: To probe into the effects of linazolamine combined with Shenfu injection intervention on serum tumor necrosis factor α（TNF-α）

procalcitonin（PCT）

hypersensitivity C-reactive protein（hs-CRP） levels and and acute physiological and chronic health evaluation Ⅱ（APACHE Ⅱ） score in patients with sepsis. METHODS: Totally 197 patients with sepsis admitted into Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine Hospital from Jan. 2019 in Jan. 2021 were selected for retrospectively analysis

which were divided into control group and observation group according to the admission time. The 98 patients in the control group were treated with linazolamine injection

while the 99 patients in the observation group was given linazolamine combined with Shenfu injection. Changes of TNF-α

PCT

hs-CRP levels and APACHE Ⅱ score before and after treatment were compared between two groups. RESULTS: The serum TNF-α

PCT

hs-CRP levels and APACHE Ⅱ score in the observation group were significantly lower than those of the control group

with statistically significant differences（P<0.05）. All the TNF-α

PCT

hs-CRP levels and APACHE Ⅱ score were independent risk factors affecting the prognosis of patients with sepsis（P<0.05）

the APACHE Ⅱ score was positively associated with TNF-α

PCT and hs-CRP expression（P<0.05）. CONCLUSIONS: All the TNF-α

PCT

hs-CRP expression and APACHE Ⅱ score were independent risk factors of patients with sepsis

and the treatment of linazolamine combined with Shenfu injection can improve the clinical efficacy.