OBJECTIVE: To probe into the effects of Glucosamine sulfate capsules and diacerein capsules combined with compound Duhuo syrup on pain degree in patients with knee osteoarthritis. METHODS: A total of 120 patients with knee osteoarthritis admitted to The Department of Orthopedics and Traumatology of Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from Mar. 2019 to Mar. 2021 were selected and divided into control group and observation group via random number table

with 60 cases in each group. The control group was treated with Glucosamine sulfate capsule combined with diacerein capsules

while the observation group was given compound Duhuo syrup on the basis of the control group. The knee pain scores

traditional Chinese medicine（TCM）syndrome integral

inflammatory factor levels and knee function scores were observed in the two groups. RESULTS: After 1 month

6 months and 1 year of treatment

the knee pain scores of both groups were significantly lower than those before treatment

and the knee pain score of observation group were significantly lower than that of the control group at each time point after treatment

with statistically significant differences（P<0.05）. After 1 month of treatment

the TCM syndrome integral

interleukin-1

interleukin-6

tumor necrosis factor α

C-reactive protein and knee function scores of both groups were significantly lower than those before treatment

and those of the observation group were significantly lower than the control group

with statistically significant differences（P<0.05）. CONCLUSIONS: Glucosamine sulfate capsules and diacerein capsules combined with compound Duhuo syrup in the treatment of knee osteoarthritis can significantly relieve joint pain and improve joint function

effectively inhibit inflammatory factor levels and delay disease progression.