Application of Chemometrics in Comprehensive Quality Evaluation of Sanhuang Tablets

WU Weikui; YAN Qianru; SONG Wei

doi:10.14009/j.issn.1672-2124.2022.05.010

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Application of Chemometrics in Comprehensive Quality Evaluation of Sanhuang Tablets

更新时间：2022-10-08

- Application of Chemometrics in Comprehensive Quality Evaluation of Sanhuang Tablets
- Vol. 22, Issue 5, Pages: 560-562(2022)
- 作者机构：
  
  1. 梅州市食品药品监督检验所中药室
  2. 梅州市食品药品监督检验所生测室和化妆品室
  3. 武汉大学人民医院药学部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.05.010
  CLC： R286.0
- Published：2022，
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WU Weikui, YAN Qianru, SONG Wei. Application of Chemometrics in Comprehensive Quality Evaluation of Sanhuang Tablets. [J]. 22(5):560-562(2022)
DOI：

WU Weikui, YAN Qianru, SONG Wei. Application of Chemometrics in Comprehensive Quality Evaluation of Sanhuang Tablets. [J]. 22(5):560-562(2022) DOI： 10.14009/j.issn.1672-2124.2022.05.010.

摘要

目的：基于灰色关联分析、总评归一值和聚类分析，评价不同厂家三黄片的质量。方法：测定5个省份13个厂家30个批次样品中盐酸小檗碱、黄芩苷、大黄素和大黄酚的含量，构建灰色关联分析、总评归一值和聚类分析质量评价模型。结果：建立了三黄片的质量评价模型，聚类分析可初步分类，灰色关联分析与总评归一值可细化排序，3种方法可相互补充。结论：化学计量学适用于三黄片质量综合评价。

Abstract

OBJECTIVE: Grey relational analysis（GRA）

overall desirability（OD） and cluster analysis were used to evaluate the quality of Sanhuang tablets from different manufacturers. METHODS: The contents of berberine hydrochloride

baicalin

rheum emodin and chrysophanol in 30 batches of samples from 13 manufacturers in 5 provinces were determined

and the quality evaluation model of GRA

OD and cluster analysis were constructed. RESULTS: The quality evaluation model of Sanhuang tablets was established

cluster analysis was used to perform initially classified

GRA and OD were used to refine the ranking

the three methods could complement each other. CONCLUSIONS: Chemometrics is applicable to the comprehensive quality evaluation of Sanhuang tablets.

关键词

三黄片质量评价化学计量学灰色关联分析总评归一值聚类分析

Keywords

Sanhuang tabletsQuality evaluationChemometricsGrey relational analysisOverall desirabilityCluster analysis

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