Literature Review on Adverse Drug Reactions of Liver Injury Induced by Radix Polygoni Multiflori Decoction Pieces and Its Preparations

NI Jianteng; MA Zhijie; DING Yao; XU Chunmei

doi:10.14009/j.issn.1672-2124.2022.04.022

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Literature Review on Adverse Drug Reactions of Liver Injury Induced by Radix Polygoni Multiflori Decoction Pieces and Its Preparations

更新时间：2022-10-08

- Literature Review on Adverse Drug Reactions of Liver Injury Induced by Radix Polygoni Multiflori Decoction Pieces and Its Preparations
- Vol. 22, Issue 4, Pages: 483-486(2022)
- 作者机构：
  
  首都医科大学附属北京友谊医院中药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.04.022
  CLC： R285.6
- Published：2022，
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NI Jianteng, MA Zhijie, DING Yao, et al. Literature Review on Adverse Drug Reactions of Liver Injury Induced by Radix Polygoni Multiflori Decoction Pieces and Its Preparations. [J]. 22(4):483-486(2022)
DOI：

NI Jianteng, MA Zhijie, DING Yao, et al. Literature Review on Adverse Drug Reactions of Liver Injury Induced by Radix Polygoni Multiflori Decoction Pieces and Its Preparations. [J]. 22(4):483-486(2022) DOI： 10.14009/j.issn.1672-2124.2022.04.022.

摘要

目的：了解何首乌饮片及其制剂所致肝损伤不良反应的情况，为临床合理用药提供参考。方法：以“何首乌肝损伤”为检索词，检索1989—2020年万方数据库、维普数据库和中国知网的相关不良反应病例报告，记录患者性别、年龄、用药时间和不良反应发生次数，并对数据进行χ

检验。结果：共检索到文献48篇，病例57例。何首乌饮片及其制剂所致肝损伤不良反应的发生次数与患者性别、年龄均无明显关系（P

0.05）

与用药时间有明显关系（P

0.05）。结论：何首乌饮片及其制剂所致肝损伤不良反应不容忽视，临床应用时应密切关注患者服药后的反应，以降低不良反应发生率，保证患者用药安全。

Abstract

OBJECTIVE: To investigate the adverse drug reactions of liver injury induced by radix polygoni multiflori decoction pieces and its preparations

so as to provide reference for rational drug use in clinic. METHODS: Case reports of adverse drug reactions in Wanfang Data

VIP and CNKI from 1989 to 2020 were retrieved by using the keyword “liver injury induced by radix polygoni multiflori”. Gender

age

duration of medication and frequency of adverse drug reactions were recorded

and the data were analyzed by χ~2 test. RESULTS: A total of 48 literature and 57 cases were retrieved. The frequency of adverse drug reactions of liver injury induced by radix polygoni multiflori decoction pieces and its preparations was not significantly related to the gender and age of the patients（P>0.05）

but was significantly related to the duration of medication（P<0.05）. CONCLUSIONS: Adverse drug reactions of liver injury induced by radix polygoni multiflori decoction pieces and its preparations can not be ignored. In clinical application

close attention should be paid to the reaction of patients after taking the medicine to reduce the incidence of adverse drug reactions and ensure the safety of medication.

关键词

何首乌肝损伤不良反应文献分析

Keywords

Radix polygoni multifloriLiver injuryAdverse drug reactionsLiterature review

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