Effects of Liangxue Huoxue Recipe Application on Expression of Serum Cytokines and Oxidative Stress in Patients with Acute Gouty Arthritis of Dampness-Heat Accumulation Type

LI Qian; DI Shengxia; ZHANG Yidong; ZHANG Jun; LIANG Hui

doi:10.14009/j.issn.1672-2124.2022.04.011

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Effects of Liangxue Huoxue Recipe Application on Expression of Serum Cytokines and Oxidative Stress in Patients with Acute Gouty Arthritis of Dampness-Heat Accumulation Type

更新时间：2022-10-08

- Effects of Liangxue Huoxue Recipe Application on Expression of Serum Cytokines and Oxidative Stress in Patients with Acute Gouty Arthritis of Dampness-Heat Accumulation Type
- Vol. 22, Issue 4, Pages: 435-439(2022)
- 作者机构：
  
  1. 石家庄市中医院骨三科
  2. 石家庄市中医院放射科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.04.011
  CLC： R259
- Published：2022，
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LI Qian, DI Shengxia, ZHANG Yidong, et al. Effects of Liangxue Huoxue Recipe Application on Expression of Serum Cytokines and Oxidative Stress in Patients with Acute Gouty Arthritis of Dampness-Heat Accumulation Type. [J]. 22(4):435-439(2022)
DOI：

LI Qian, DI Shengxia, ZHANG Yidong, et al. Effects of Liangxue Huoxue Recipe Application on Expression of Serum Cytokines and Oxidative Stress in Patients with Acute Gouty Arthritis of Dampness-Heat Accumulation Type. [J]. 22(4):435-439(2022) DOI： 10.14009/j.issn.1672-2124.2022.04.011.

摘要

目的：探讨凉血活血方敷贴对湿热蕴结型急性痛风性关节炎患者血清细胞因子、氧化应激表达的影响。方法：选取2019年1月至2021年6月于该院住院治疗的112例急性痛风性关节炎患者纳入研究，将其分为观察组和对照组，每组56例。对照组患者采用基础治疗方案，观察组患者除基础治疗方案外采用凉血活血方敷贴进行治疗，两组患者均连续治疗7 d。对比两组患者治疗前和疗程结束后的中医症状积分、丙二醛(MDA)、3-硝基络氨酸修饰蛋白(3-NT)、8-羟基脱氧鸟苷(8-OHdG)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、血尿酸、红细胞沉降率(ESR)以及超敏C反应蛋白(hs-CRP)水平，观察临床疗效。结果：治疗后，两组患者关节疼痛、关节发热、关节肿胀、关节活动、肢体困重、口渴和小便短黄等中医症状积分均显著降低，且观察组患者显著低于对照组，差异均有统计学意义(P<0.05)。治疗后，观察组患者的总有效率为96.43%(54/56)

显著高于对照组的85.71%(48/56)

差异有统计学意义(P<0.05)。治疗后，两组患者IL-6、TNF-α、hs-CRP、血尿酸和ESR水平均较治疗前显著降低，且观察组患者显著低于对照组，差异均有统计学意义(P<0.05)。治疗后，两组患者MDA、3-NT和8-OHdG水平均较治疗前显著降低，且观察组患者显著低于对照组，差异均有统计学意义(P<0.05)。结论：凉血活血方敷贴对湿热蕴结型急性痛风性关节炎的疗效较好，可显著改善患者的临床症状，降低氧化应激表达，调节机体炎症因子表达水平。

Abstract

OBJECTIVE: To probe into the effects of Liangxue Huoxue recipe application on expression of serum cytokines and oxidative stress in patients with acute gouty arthritis of dampness-heat accumulation type. METHODS: Totally 112 patients with acute gouty arthritis admitted into the hospital from Jan. 2019 to Jun. 2021 were extracted to be divided into the observation group and the control group

with 56 cases in each group. The control group was treated with basic treatment regimen

while the observation group received the application of Liangxue Huoxue recipe application based on the basic treatment regimen. Both groups were treated for 7 d. Traditional Chinese medicine symptom scores

malondialdehyde（MDA）

3-nitrotyrosine modified protein（3-NT）

8-hydroxydeoxyguanosine（8-OHdG）

interleukin-6（IL-6）

tumor necrosis factor alpha（TNF-α）

uric acid（UA）

erythrocyte sedimentation rate（ESR）

and high-sensitivity C-reactive protein（hs-CRP） levels before and after treatment were compared between two groups. The clinical efficacy was observed. RESULTS: After treatment

the traditional Chinese medicine symptom scores such as joint pain

joint fever

joint swelling

joint movement

limb heaviness

thirst and short urine decreased significantly in two groups

while the observation group was significantly lower than the control group

the differences were statistically significant（P<0.05）. After treatment

the total effective rate of the observation group was 96.43%（54/56）

significantly higher than 85.71%（48/56） of the control group

the difference was statistically significant（P<0.05）. After treatment

the levels of IL-6

TNF-α

hs-CRP

UA and ESR were significantly lower in both groups than those before treatment

and the observation group was significantly lower than the control group

with statistically significant differences（P<0.05）. After treatment

the levels of MDA

3-NT and 8-OHDG in both groups were significantly lower than those before treatment

and the observation group was significantly lower than the control group

the differences were statistically significant（P<0.05）. CONCLUSIONS: The application of Liangxue Huoxue recipe application on patients with acute gouty arthritis of dampness-heat accumulation type can significantly improve patients’ clinical symptoms

reduce the expression of oxidative stress and regulate the expression level of inflammatory factors.

关键词

急性痛风性关节炎凉血活血方敷贴中西医结合细胞因子氧化应激

Keywords

Acute gouty arthritisLiangxue Huoxue recipe applicationCombination of traditional Chinese and western medicineCytokinesOxidative stress

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