“Expert Consensus on Risk Assessment of Drugs in Pregnancy in China” Based on the Delphi Method

DU Boran; LI Yifan; SHI Xiangjun; FENG Xin; YIN Chenghong

doi:10.14009/j.issn.1672-2124.2022.04.001

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“Expert Consensus on Risk Assessment of Drugs in Pregnancy in China” Based on the Delphi Method

更新时间：2022-10-08

- “Expert Consensus on Risk Assessment of Drugs in Pregnancy in China” Based on the Delphi Method
- Vol. 22, Issue 4, Pages: 385-388(2022)
- 作者机构：
  
  1. 首都医科大学附属北京妇产医院/北京妇幼保健院药事部
  2. 清华大学医学院
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.04.001
  CLC： R95
- Published：2022，
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DU Boran, LI Yifan, SHI Xiangjun, et al. “Expert Consensus on Risk Assessment of Drugs in Pregnancy in China” Based on the Delphi Method. [J]. 22(4):385-388(2022)
DOI：

DU Boran, LI Yifan, SHI Xiangjun, et al. “Expert Consensus on Risk Assessment of Drugs in Pregnancy in China” Based on the Delphi Method. [J]. 22(4):385-388(2022) DOI： 10.14009/j.issn.1672-2124.2022.04.001.

摘要

目的：基于德尔菲法构建《中国妊娠期药物风险评估专家共识》

为进一步开展妊娠期药物风险评估研究提供方法学基础。方法：参考妊娠期药物风险评估研究相关文献，撰写《中国妊娠期药物风险评估专家共识》

并设计专家咨询问卷。选取北京、上海等省市51名专家，应用德尔菲法进行两轮专家咨询，对《中国妊娠期药物风险评估专家共识》的内容进行修改。结果：两轮问卷回收率为100%

专家权威系数（Cr）为0.80±0.10

专家意见的变异系数（CV）第1轮为0.15±0.04

第2轮为0.13±0.03

专家意见的协调系数（Kendall-W）第1轮为0.170

第2轮为0.493

两轮专家意见协调系数的χ

检验结果显示差异均具有统计学意义（P

0.001）

最终确定《中国妊娠期药物风险评估专家共识》。结论：应用德尔菲法构建《中国妊娠期药物风险评估共识》

为开展中国妊娠期药物风险评估提供了方法学基础。

Abstract

OBJECTIVE: To establish the “Expert Consensus on Risk Assessment of Drugs in Pregnancy in China” based on the Delphi method

so as to provide methodological basis for further studies on drug risk assessment in pregnancy. METHODS: By referring to the literature related to drug risk assessment in pregnancy

the “Expert Consensus on Risk Assessment of Drugs in Pregnancy in China” was established

and the expert consultation questionnaire was designed. Fifty-one experts from Beijing

Shanghai and other provinces and cities were selected to apply the Delphi method for two rounds of expert consultation to revise the content of the “Expert Consensus on Risk Assessment of Drugs in Pregnancy in China”. RESULTS: The recovery rates of the two rounds of questionnaire were 100%. The expert authority coefficient（Cr） was 0.80±0.10

the coefficient of variation（CV） of expert opinion was 0.15±0.04 in the first round and 0.13±0.03 in the second round

and the coordination coefficient of expert opinion（Kendall-W） was 0.170 in the first round and 0.493 in the second round.In both rounds

Chi-square test showed statistically significant differences（P<0.001）. Finally

the “Expert Consensus on Risk Assessment of Drugs in Pregnancy in China” was determined. CONCLUSIONS: The Delphi method is used to establish the “Expert Consensus on Risk Assessment of Drugs in Pregnancy in China”

which provides methodological basis for the risk assessment of drugs during pregnancy in China.

关键词

德尔菲法中国妊娠期药物风险评估专家共识评估指标

Keywords

Delphi methodRisk assessment of drugs in pregnancy in ChinaExpert consensusAssessment indicators

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