Adverse Drug Reactions Induced by Linezolid in 84 Patients with Drug-Resistant Tuberculosis

CHENG Kai; LI Na; CHEN Xiaoyou; MU Xiaopan; GUO Zhenyong

doi:10.14009/j.issn.1672-2124.2022.03.026

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Adverse Drug Reactions Induced by Linezolid in 84 Patients with Drug-Resistant Tuberculosis

更新时间：2022-10-08

- Adverse Drug Reactions Induced by Linezolid in 84 Patients with Drug-Resistant Tuberculosis
- Vol. 22, Issue 3, Pages: 374-377(2022)
- 作者机构：
  
  1. 北京市结核病胸部肿瘤研究所/首都医科大学附属北京胸科医院药剂科
  2. 首都医科大学附属北京友谊医院药剂科
  3. 首都医科大学附属北京地坛医院医务处
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.03.026
  CLC： R969
- Published：2022，
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CHENG Kai, LI Na, CHEN Xiaoyou, et al. Adverse Drug Reactions Induced by Linezolid in 84 Patients with Drug-Resistant Tuberculosis. [J]. 22(3):374-377(2022)
DOI：

CHENG Kai, LI Na, CHEN Xiaoyou, et al. Adverse Drug Reactions Induced by Linezolid in 84 Patients with Drug-Resistant Tuberculosis. [J]. 22(3):374-377(2022) DOI： 10.14009/j.issn.1672-2124.2022.03.026.

摘要

目的：了解利奈唑胺导致耐药结核病患者发生药品不良反应(ADR)的特点和规律，促进临床合理用药。方法：采用回顾性分析方法，收集2016年12月至2021年3月首都医科大学附属北京胸科医院84例使用利奈唑胺发生ADR的耐药结核病患者资料，对患者性别、年龄、给药途径、用法与用量、累及器官和(或)系统及临床表现、血药浓度监测等数据进行统计分析。结果：84例发生ADR的患者中，男女比例为1∶1.21;平均年龄为(65.6±10.7)岁，>60岁患者所占比例最高(49例，占58.33%);口服给药引起的ADR最多(67例，占79.76%)。利奈唑胺所致ADR累及多个器官和(或)系统，临床表现共159例次，主要为血液系统损害(55例次，占34.59%)

其次为视觉系统损害(29例次，18.24%)和神经系统损害(27例次，占16.98%)。仅有31例患者(占36.90%)进行了血药浓度监测。结论：利奈唑胺所致ADR的临床表现多样，可在治疗期间进行血药浓度监测，尤其是特殊患者更需注意ADR监测，促进临床合理用药。

Abstract

OBJECTIVE: To investigate the characteristics and regularities of adverse drug reactions（ADR） induced by linezolid in patients with drug-resistant tuberculosis

so as to promote the clinical rational drug use. METHODS: Retrospective analysis method was used

data of 84 drug-resistant tuberculosis patients with ADR induced by linezolid in Beijing Chest Hospital Affiliated to Capital Medical University from Dec. 2016 to Mar. 2021 were collected

and statistical analysis was performed on the data of gender

age

route of administration

usage and dosage

involved organs and（or） systems

clinical manifestations and blood concentration monitoring. RESULTS: Of the 84 patients with ADR

the male to female ratio was 1∶ 1.21. The average age was（65.6±10.7） years

and the proportion of patients >60 years was the highest（49 cases

58.33%）. The most ADR was induced by oral administration（67 cases

79.76%）. ADR induced by linezolid involved multiple organs and（or） systems

with 159 case-times of clinical manifestations

mainly blood system damage（55 case-times

34.59%）

followed by visual system damage（29 case-times

18.24%） and nervous system damage（27 case-times

16.98%）. Only 31 patients（36.90%） received blood concentration monitoring. CONCLUSIONS: Clinical manifestations of ADR induced by linezolid are diverse

and blood drug concentration monitoring can be performed during treatment. Especially in special patients

more attention should be paid to ADR monitoring to promote clinical rational drug use.

关键词

利奈唑胺药品不良反应血药浓度监测合理用药

Keywords

LinezolidAdverse drug reactionsBlood concentration monitoringRational drug use

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