Systematic Review on Efficacy and Safety of Mecobalamin Tablets Combined with Mudan Granules in the Treatment of Diabetic Peripheral Neuropathy

doi:10.14009/j.issn.1672-2124.2022.03.023

您当前的位置：

首页 >

文章列表页 >

Systematic Review on Efficacy and Safety of Mecobalamin Tablets Combined with Mudan Granules in the Treatment of Diabetic Peripheral Neuropathy

更新时间：2022-10-08

- Systematic Review on Efficacy and Safety of Mecobalamin Tablets Combined with Mudan Granules in the Treatment of Diabetic Peripheral Neuropathy
- Vol. 22, Issue 3, Pages: 356-363(2022)
- 作者机构：
  
  1. 北京医院药学部国家老年医学中心中国医学科学院老年医学研究院北京市药物临床风险与个体化应用评价重点实验室(北京医院)
  2. 北京医院检验科国家老年医学中心中国医学科学院老年医学研究院
  3. 北京医院中医科国家老年医学中心中国医学科学院老年医学研究院
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.03.023
  CLC： R747.9;R587.2
- Published：2022，
扫描看全文
Systematic Review on Efficacy and Safety of Mecobalamin Tablets Combined with Mudan Granules in the Treatment of Diabetic Peripheral Neuropathy. [J]. 22(3):356-363(2022)
DOI：

Systematic Review on Efficacy and Safety of Mecobalamin Tablets Combined with Mudan Granules in the Treatment of Diabetic Peripheral Neuropathy. [J]. 22(3):356-363(2022) DOI： 10.14009/j.issn.1672-2124.2022.03.023.

摘要

目的：系统评价甲钴胺片联合木丹颗粒治疗糖尿病周围神经病变的有效性和安全性。方法：计算机检索Embase、PubMed、the Cochrane Library、万方数据库、中国知网和中国生物医学文献数据库，收集从建库至2022年3月发表的甲钴胺片联合木丹颗粒治疗糖尿病周围神经病变的随机对照试验(RCT)研究(研究组患者采用甲钴胺片联合木丹颗粒治疗，对照组患者单纯使用甲钴胺片治疗)

中文数据库限定为中国科技论文统计源期刊，英文数据库不做期刊限制。选取文献、提取资料并评价纳入文献的偏倚风险后，采用RevMan 5.4软件进行Meta分析。结果：共纳入13项研究，包括1 438例患者，研究组745例，对照组693例。Meta分析结果显示，有效性方面，研究组患者在总有效率(OR=3.31

95%CI=2.41～4.55

P<0.000 01)、显效率(OR=2.23

95%CI=1.72～2.90

P<0.000 01)、正中神经运动传导速度(MD=2.91

95%CI=2.22～3.59

P<0.000 01)、腓总神经运动传导速度(MD=4.94

95%CI=2.84～7.03

P<0.000 01)、胫前神经运动传导速度(MD=2.87

95%CI=2.22～3.52

P<0.000 01)、正中神经感觉传导速度(MD=3.95

95%CI=3.42～4.48

P<0.000 01)、腓总神经感觉传导速度(MD=5.11

95%CI=1.84～8.38

P=0.002)和胫前神经感觉传导速度(MD=4.81

95%CI=3.89～5.73

P<0.000 01)等方面显著优于对照组，差异均有统计学意义；安全性方面，研究组患者的不良反应发生率显著低于对照组，差异有统计学意义(OR=0.34

95%CI=0.14～0.83

P=0.02)。结论：现有证据表明，甲钴胺片联合木丹颗粒治疗糖尿病周围神经病变安全、有效，较单纯使用甲钴胺片有显著优势。因选取的研究数量和质量的限制，上述结论有待今后更多高质量RCT进行验证。

Abstract

OBJECTIVE: To systematically evaluate the efficacy and safety of Mecobalamin tablets combined with Mudan granules in the treatment of diabetic peripheral neuropathy. METHODS: Embase

PubMed

the Cochrane Library

Wanfang Data

CNKI and CBM databases were retrieved to collect the randomized controlled trial（RCT） of Mecobalamin tablets combined with Mudan granules in the treatment of diabetic peripheral neuropathy（the study group was treated with Mecobalamine tablets combined with Mudan granules

while the control group received Mecobalamine tablets alone）

the retrieval time was from the establishment of the database to Mar. 2022. The Chinese database was limited to the statistical source journals of Chinese scientific and technical papers

and the English database did not make journal restrictions. After literature selection

data extraction and bias risk evaluation of included literature

RevMan 5.4 software was used for Meta-analysis. RESULTS: A total of 13 studies were enrolled

including 1 438 patients

with 745 cases in the study group and 693 cases in the control group. In terms of efficacy

the total effective rate（OR=3.31

95%CI=2.41-4.55

P<0.000 01）

significant effective rate（OR=2.23

95%CI=1.72-2.90

P<0.000 01）

motor conduction velocity（MCV） of median nerve（MD=2.91

95%CI=2.22-3.59

P<0.000 01）

MCV of common peroneal nerve（MD=4.94

95%CI=2.84-7.03

P<0.000 01）

MCV of anterior tibial nerve（MD=2.87

95%CI=2.22-3.52

P<0.000 01）

sensory conduction velocity（SCV） of median nerve（MD=3.95

95%CI=3.42-4.48

P<0.000 01）

SCV of common peroneal nerve（MD=5.11

95%CI=1.84-8.38

P=0.002） and SCV of anterior tibial nerve（MD=4.81

95%CI=3.89-5.73

P<0.000 01） in the study group were significantly better than those in the control group

the differences were statistically significant. In terms of safety

the incidence of adverse drug reactions in the study group was significantly lower than that in the control group

with statistically significant difference（OR=0.34

95%CI=0.14-0.83

P=0.02）. CONCLUSIONS: The available evidence suggests that Mecobalamin tablets combined with Mudan granules are safe and effective in the treatment of diabetic peripheral neuropathy

with significant advantages over Mecobalamin tablets alone. Due to the limitations of the number and quality of selected studies

the above findings need to be validated by more high-quality RCT in the future.

关键词

甲钴胺片木丹颗粒糖尿病周围神经病变Meta分析随机对照试验

Keywords

Mudan granulesMecobalamin tabletsDiabetic peripheral neuropathyMeta-analysisRandomized controlled trial

references

查看原文

Views

127

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Meta-Analysis of Efficacy and Safety of Ticagrelor Combined with Rosuvastatin Therapy in the Treatment of Unstable Angina Pectoris

Systematic Review on Efficacy and Safety of Huangqi Guizhi Wuwu Decoction Combined with Acupuncture in the Treatment of Diabetic Peripheral Neuropathy

Systematic Review of Efficacy and Safety of Linezolid in the Treatment of Drug-Resistant Tuberculosis

Systematic Review of Efficacy and Safety of Azelastine Hydrochloride Combined with Mometasone Furoate in the Treatment of Allergic Rhinitis

Systematic Review on Efficacy and Safety of Silybin Capsules in the Treatment of Fatty Liver Disease

Related Author

LUO Ruixiang

ZHANG Chen

WU Yang

FAN Zongjing

CUI Jie

QU Xinliang

ZHAO Bo

DUAN Guangjing

Related Institution

North District Branch,Beijing Emergency Medical Center

School of Clinical Medicine, Beijing University of Traditional Chinese Medicine

Dept. of Cardiology, Dongfang Hospital of Beijing University of Traditional Chinese Medicine

College of Pharmacy, Shaanxi University of Chinese Medicine

Dept. of Pharmacy, Beijing Friendship Hospital Affiliated to Capital Medical University

⁰