Systematic Review on Efficacy and Safety of Compound Glycyrrhizin Injection in Adjuvant Treatment of Children with Henoch-Schonlein Purpura

REN Xiangge; HE Mei; JI Cong; ZHAI Wensheng

doi:10.14009/j.issn.1672-2124.2022.03.022

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Systematic Review on Efficacy and Safety of Compound Glycyrrhizin Injection in Adjuvant Treatment of Children with Henoch-Schonlein Purpura

更新时间：2022-10-08

- Systematic Review on Efficacy and Safety of Compound Glycyrrhizin Injection in Adjuvant Treatment of Children with Henoch-Schonlein Purpura
- Vol. 22, Issue 3, Pages: 350-355(2022)
- 作者机构：
  
  1. 河南中医药大学儿科医学院
  2. 河南中医药大学第一附属医院儿科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.03.022
  CLC： R725.5
- Published：2022，
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REN Xiangge, HE Mei, JI Cong, et al. Systematic Review on Efficacy and Safety of Compound Glycyrrhizin Injection in Adjuvant Treatment of Children with Henoch-Schonlein Purpura. [J]. 22(3):350-355(2022)
DOI：

REN Xiangge, HE Mei, JI Cong, et al. Systematic Review on Efficacy and Safety of Compound Glycyrrhizin Injection in Adjuvant Treatment of Children with Henoch-Schonlein Purpura. [J]. 22(3):350-355(2022) DOI： 10.14009/j.issn.1672-2124.2022.03.022.

摘要

目的：通过Meta分析方法，系统评价复方甘草酸苷注射液辅助治疗儿童过敏性紫癜(HSP)的有效性和安全性。方法：系统检索中国知网、万方数据库、维普数据库、PubMed、Embase、Web of science和the Cochrane Library等数据库，收集复方甘草酸苷注射液辅助治疗儿童HSP的随机对照试验(对照组患儿采用常规治疗，治疗组患儿在对照组的基础上加用复方甘草酸苷注射液)。制定严格的纳入与排除标准，筛选纳入文献并进行质量评价，分别使用RevMan 5.4.1、Stata 16.0统计软件进行Meta分析和发表偏倚分析。结果：本研究最终纳入19篇文献，共1 405例患儿，其中治疗组患儿714例，对照组患儿691例。Meta分析结果表明，复方甘草酸苷注射液联合常规治疗的临床有效率明显优于单纯常规治疗，差异有统计学意义(RR=1.25

95%CI=1.19～1.30

P<0.000 01);与单纯常规治疗比较，复方甘草酸苷注射液联合常规治疗可缩短患儿的皮肤紫癜消失时间(MD=-3.29

95%CI=-4.81～-1.77

P<0.000 1)、关节肿痛消失时间(MD=-2.00

95%CI=-2.71～-1.30

P<0.000 01)和腹痛消失时间(MD=-1.64

95%CI=-2.33～-0.95

P<0.000 01)

差异均有统计学意义；安全性方面，两组患儿不良反应发生率的差异无统计学意义(RR=1.56

95%CI=0.06～37.67

P=0.78)。结论：在常规治疗的基础上联合使用复方甘草酸苷注射液可提高儿童HSP的临床治疗效果，且不良反应轻微，安全性较高。

Abstract

OBJECTIVE: To systematically review the efficacy and safety of compound glycyrrhizin injection in adjuvant treatment of children with henoch-schonlein purpura（HSP） by Meta-analysis. METHODS: CNKI

Wanfang Data

VIP

PubMed

Embase

Web of Science

the Cochrane Library and other databases were retrieved to collect the randomized controlled trial of compound glycyrrhizin injection in adjuvant treatment of children with HSP（the control group received conventional treatment

and the treatment group was additionally given compound glycyrrhizin injection on the basis of the control group）. Strict inclusion and exclusion criteria were established to screen the included literature and evaluate the quality. Meta-analysis and publication bias analysis were performed by using RevMan 5.4.1 and Stata 16.0 statistical software

respectively. RESULTS: This study finally included 19 literature with a total of 1 405 children

including 714 children in the treatment group and 691 children in the control group. Meta-analysis showed that the clinical effective rate of compound glycyrrhizin injection combined with conventional treatment was significantly better than that of conventional treatment alone

with statistically significant differences（RR=1.25

95%CI=1.19-1.30

P<0.000 01）. Compared with the conventional treatment alone

compound glycyrrhizin injection combined with conventional treatment can shorten the disappearance time of HSP in children（MD=-3.29

95%CI=-4.81--1.77

P<0.000 1）

and the disappearance time of joint swelling and pain（MD=-2.00

95%CI=-2.71--1.30

P<0.000 01） and disappearance time of abdominal pain（MD=-1.64

95%CI=-2.33--0.95

P<0.000 01）

the differences were statistically significant. In terms of safety

there was no statistically significant difference in the incidence of adverse drug reactions between two groups（RR=1.56

95%CI=0.06-37.67

P=0.78）. CONCLUSIONS: Compound glycyrrhizin injection combined with conventional treatment can improve the clinical treatment effects of children with HSP

with mild adverse drug reactions and higher safety.

关键词

复方甘草酸苷注射液过敏性紫癜儿童有效性安全性Meta分析

Keywords

Compound glycyrrhizin injectionHenoch-schonlein purpuraChildrenEfficacySafetyMeta-analysis

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