Acupoint Application Combined with Xuefuzhuyu Decoction in the Treatment of Patients with Primary Dysmenorrhea of Qi-Stagnation and Blood-Stasis Syndrome

LANG Yanhua; ZHANG Huanhuan; LI Li

doi:10.14009/j.issn.1672-2124.2022.03.008

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Acupoint Application Combined with Xuefuzhuyu Decoction in the Treatment of Patients with Primary Dysmenorrhea of Qi-Stagnation and Blood-Stasis Syndrome

更新时间：2022-10-08

- Acupoint Application Combined with Xuefuzhuyu Decoction in the Treatment of Patients with Primary Dysmenorrhea of Qi-Stagnation and Blood-Stasis Syndrome
- Vol. 22, Issue 3, Pages: 289-292(2022)
- 作者机构：
  
  1. 广州中医药大学第一临床医学院
  2. 广州中医药大学第一附属医院妇科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.03.008
  CLC： R271.113
- Published：2022，
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LANG Yanhua, ZHANG Huanhuan, LI Li. Acupoint Application Combined with Xuefuzhuyu Decoction in the Treatment of Patients with Primary Dysmenorrhea of Qi-Stagnation and Blood-Stasis Syndrome. [J]. 22(3):289-292(2022)
DOI：

LANG Yanhua, ZHANG Huanhuan, LI Li. Acupoint Application Combined with Xuefuzhuyu Decoction in the Treatment of Patients with Primary Dysmenorrhea of Qi-Stagnation and Blood-Stasis Syndrome. [J]. 22(3):289-292(2022) DOI： 10.14009/j.issn.1672-2124.2022.03.008.

摘要

目的：探讨穴位贴敷联合血府逐瘀汤治疗原发性痛经气滞血瘀证的临床疗效。方法：选取2019年6月至2020年12月广州中医药大学第一附属医院收治的原发性痛经患者102例，通过随机数字表法分为对照组和研究组，每组51例。对照组患者给予血府逐瘀汤治疗，研究组患者给予穴位贴敷联合血府逐瘀汤治疗。治疗后对两组患者进行临床疗效评价，并观察治疗期间不良反应发生情况；比较两组患者治疗前后疼痛视觉模拟评分(VAS)、中医证候评分，血清前列腺素E2(PGE2)、前列腺素F2α(PGF2α)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和超敏C反应蛋白(hs-CRP)水平。结果：研究组患者的总有效率为96.08%(49/51)

明显较对照组(80.39%

41/51)高，差异有统计学意义(P<0.05)。治疗后，研究组患者VAS评分、中医证候评分均明显较对照组低，血清PGE2水平明显较对照组高，血清PGF2α、TNF-α、IL-6及hs-CRP水平明显较对照组低，差异均有统计学意义(P<0.05)。治疗期间，两组患者均无严重的不良反应发生。结论：穴位贴敷联合血府逐瘀汤治疗原发性痛经可显著提高疗效，改善患者症状，缓解疼痛，抑制炎症反应，调节血清前列腺代谢物水平，且安全性较好。

Abstract

OBJECTIVE: To probe into the clinical efficacy of acupoint application combined with Xuefuzhuyu decoction in the treatment of patients with primary dysmenorrhea of Qi-stagnation and blood-stasis syndrome. METHODS: Totally 102 patients with primary dysmenorrhea admitted into the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from Jun. 2019 to Dec. 2020 were extracted to be divided into the control group and the study group via the random number table

with 51 cases in each group. The control group was given Xuefuzhuyu decoction

while the study group received acupoint application combined with Xuefuzhuyu decoction. After treatment

the clinical efficacy of two groups were evaluated

and the occurrence of adverse drug reactions during treatment was observed. The visual analogue scale（VAS）

traditional Chinese medicine symptom score and levels of serum prostaglandin E2（PGE2）

prostaglandin F2α（PGF2α）

tumor necrosis factor α（TNF-α）

interleukin-6（IL-6） and high-sensitivity C-reactive protein（hs-CRP） of two groups were compared before and after treatment. RESULTS: The total effective rate of the study group was 96.08%（49/51）

significantly higher than 80.39%（41/51） of the control group

the difference was statistically significant（P<0.05）. After treatment

the VAS score and traditional Chinese medicine symptom score of the study group were significantly lower than those of the control group

the level of serum PGE2 was significantly higher than that of the control group

and the levels of serum PGF2α

TNF-a

IL-6 and hs-CRP were significantly lower than those of the control group

with statistically significant differences（P<0.05）. During the treatment

no severe adverse drug reactions occurred in both groups. CONCLUSIONS: Acupoint application combined with Xuefuzhuyu decoction in the treatment of patients with primary dysmenorrhea can significantly improve the curative effect

improve patients’ symptoms

relieve the pain

inhibit the inflammatory reaction

and regulate the level of serum prostate metabolites with higher safety.

关键词

原发性痛经穴位贴敷血府逐瘀汤疗效前列腺代谢物

Keywords

Primary dysmenorrheaAcupoint applicationXuefuzhuyu decoctionEfficacyProstate metabolites

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