Effects of Modified Shaoyao Gancao Decoction Combined with Acupuncture on Inflammatory Factors in Patients with Acute Ankle Sprain

LI Binjie; ZHOU Xiaofang; HUANG Zichong

doi:10.14009/j.issn.1672-2124.2022.03.007

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Effects of Modified Shaoyao Gancao Decoction Combined with Acupuncture on Inflammatory Factors in Patients with Acute Ankle Sprain

更新时间：2022-10-08

- Effects of Modified Shaoyao Gancao Decoction Combined with Acupuncture on Inflammatory Factors in Patients with Acute Ankle Sprain
- Vol. 22, Issue 3, Pages: 286-288(2022)
- 作者机构：
  
  1. 中国人民警察大学医院外科
  2. 中国人民警察大学医院药房
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.03.007
  CLC： R274.9
- Published：2022，
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LI Binjie, ZHOU Xiaofang, HUANG Zichong. Effects of Modified Shaoyao Gancao Decoction Combined with Acupuncture on Inflammatory Factors in Patients with Acute Ankle Sprain. [J]. 22(3):286-288(2022)
DOI：

LI Binjie, ZHOU Xiaofang, HUANG Zichong. Effects of Modified Shaoyao Gancao Decoction Combined with Acupuncture on Inflammatory Factors in Patients with Acute Ankle Sprain. [J]. 22(3):286-288(2022) DOI： 10.14009/j.issn.1672-2124.2022.03.007.

摘要

目的：观察芍药甘草汤加减联合针刺疗法对急性踝关节扭伤患者炎症因子的影响。方法：选取2020年1月至2021年1月该院收治的急性踝关节扭伤患者100例，遵循随机数字表法分为观察组(芍药甘草汤加减+针刺治疗)50例和对照组(冰敷联合双氯芬酸二乙胺乳胶剂外涂治疗)50例。两组患者均治疗10 d。比较治疗前后两组患者跖屈活动度、背伸活动度、血清疼痛物质和炎症因子[白细胞介素(IL)1β、IL-6和肿瘤坏死因子α(TNF-α)]水平等。结果：治疗后，两组患者踝关节跖屈活动度、背伸活动度均较治疗前好转，且观察组患者改善情况明显优于对照组，差异均有统计学意义(P<0.05)。治疗后，所有患者的神经肽、神经生长因子和P物质均较治疗前明显降低，且观察组患者降低幅度较对照组更明显，差异均有统计学意义(P<0.05)。治疗后，所有患者的IL-1β、IL-6和TNF-α水平较治疗前降低，且观察组患者降低幅度较对照组更明显，差异均有统计学意义(P<0.05)。结论：芍药甘草汤加减联合针刺疗法可明显改善急性踝关节扭伤患者的症状，提高临床疗效，可能与降低血清炎症因子及疼痛物质水平相关。

Abstract

OBJECTIVE: To explore the effect of modified Shaoyao Gancao decoction combined with acupuncture therapy on inflammatory factors in patients with acute ankle sprain.METHODS: Totally 100 patients with acute ankle sprain admitted into the hospital from Jan. 2020 to Jan. 2021 were extracted to be divided into the observation group（Shaoyao Gancao decoction + acupuncture） and the control group（compress combined with external application of diclofenac diethylamine emulgel） via the random number table

with 50 cases in each group. Both groups were treated for 10 d. The range of motion of plantar flexion

range of dorsiflexion

serum pain substances and inflammatory factors [interleukin（IL）-1β

IL-6 and tumor necrosis factor alpha（TNF-α）] levels were compared between two groups before and after treatment. RESULTS: After treatment

the range of motion of plantar flexion and range of dorsiflexion in two groups were improved compared with those before treatment

and the improvement in the observation group was significantly better than that in the control group

with statistically significant difference（P<0.05）. After treatment

neuropeptide

nerve growth factor and substance P in all patients decreased significantly compared with those before treatment

and the reduction in the observation group was greater than that in the control group

with statistically significant difference（P<0.05）. After treatment

the levels of IL-1β

IL-6 and TNF-α in all patients decreased significantly compared with those before treatment

and the reduction in the observation group was greater than that in the control group

the differences were statistically significant（P<0.05）. CONCLUSIONS: Shaoyao Gancao decoction combined with acupuncture can significantly improve the symptoms and clinical efficacy of patients with acute ankle sprain

which may be related to the reduction of serum inflammatory factors and pain substances.

关键词

芍药甘草汤针刺急性踝关节扭伤炎症因子

Keywords

Shaoyao Gancao decoctionAcupunctureAcute ankle sprainInflammatory factors

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