OBJECTIVE: To probe into the clinical evaluation on comprehensive management mode of adverse drug reactions of highly emetogenic chemotherapy drugs in the treatment of lung cancer. METHODS: Totally 104 patients with lung cancer who were hospitalized in this hospital and received the first chemotherapy from Jun. 2019 to Sept. 2020 were prospectively extracted to be randomly divided into the study group（n=52） and the control group（n=52） by drawing lots. The study group was given comprehensive management mode

while the control group received the routine treatment mode of the oncology department. The severity of nausea

frequency of vomiting

and patient satisfaction were compared between two groups. RESULTS: One hundred and four patients were followed up for 11.1 months to 14.2 months

with an average of（12.4±1.3） months. The chemotherapy regimens of two groups were basically the same

and there was no statistically significant difference in all indicators of sociodemographic data（P>0.05）. However

the severity of nausea and frequency of vomiting in the study group were lower than those in the control group after the implementation of comprehensive management mode

the difference was statistically significant（P<0.05）. The satisfaction score of the study group was（95.24±5.98） scores

higher than（90.32±6.14） scores of the control group

the difference was statistically significant（t=3.124

P<0.01）. CONCLUSIONS: The comprehensive management mode can effectively promote the close cooperation between clinicians and nurses

and has achieved better results in reducing the severity of nausea

frequency of vomiting and improving patient satisfaction

improving the quality of vomit-free control and facilitating the smooth implementation of chemotherapy for patients.