OBJECTIVE: To probe into the clinical efficacy of Jingtong granules combined with paracervical nerve block in the treatment of cervicogenic headache. METHODS: Totally 91 patients with cervicogenic headache admitted into Liaocheng People’s Hospital from May 2019 to Oct. 2020 were extracted to be divided into 45 cases in the control group（treated with paracervical nerve block） and 46 cases in the observation group（Jingtong granules combined with peripheral nerve block） via the random number table. The clinical efficacy

improvement of clinical symptoms

cervical blood flow

inflammatory factors and adverse drug reactions of two groups were observed. RESULTS: The excellent and good rate of clinical treatment in the observation group was 84.78%（39/46）

which was significantly higher than 62.22%（28/45） in the control group

the difference was statistically significant（P<0.05）.After treatment

the average blood flow velocity in the neck of the observation group was higher than that of the control group

and the vascular pulsation index

resistance index

interleukin 6

interleukin 1β

tumor necrosis factor α

pain digital score

and headache attack frequency were lower than those in the control group

the duration of headache was shorter than that of the control group

the difference was statistically significant（P<0.05）. CONCLUSIONS: Jingtong granules combined with paracervical nerve block in the treatment of cervicogenic headache can effectively improve the clinical symptoms and cervical blood flow

and its mechanism may be related to the down-regulation of inflammatory cytokines.