Efficacy and Mechanism of Danhong Injection Combined with Conventional Therapy in Patients with Chronic Heart Failure

WANG Bingmin; HONG Weihua; WANG Guolei

doi:10.14009/j.issn.1672-2124.2022.02.017

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Efficacy and Mechanism of Danhong Injection Combined with Conventional Therapy in Patients with Chronic Heart Failure

更新时间：2022-10-08

- Efficacy and Mechanism of Danhong Injection Combined with Conventional Therapy in Patients with Chronic Heart Failure
- Vol. 22, Issue 2, Pages: 193-195(2022)
- 作者机构：
  
  1. 琼海市中医院药剂科
  2. 琼海市中医院心血管内科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.02.017
  CLC： R541.6
- Published：2022，
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WANG Bingmin, HONG Weihua, WANG Guolei. Efficacy and Mechanism of Danhong Injection Combined with Conventional Therapy in Patients with Chronic Heart Failure. [J]. 22(2):193-195(2022)
DOI：

WANG Bingmin, HONG Weihua, WANG Guolei. Efficacy and Mechanism of Danhong Injection Combined with Conventional Therapy in Patients with Chronic Heart Failure. [J]. 22(2):193-195(2022) DOI： 10.14009/j.issn.1672-2124.2022.02.017.

摘要

目的：探讨丹红注射液联合常规治疗对慢性心力衰竭患者的近期疗效及其可能机制。方法：纳入2018年6月至2020年6月于该院接受治疗的慢性心力衰竭患者120例，根据随机数字表法分为对照组、观察组，每组60例。对照组患者接受常规西医治疗，观察组患者在对照组基础上加用丹红注射液治疗。治疗4周后，比较两组患者的近期疗效、中医证候总积分、6 min步行试验距离，血清高迁移率族蛋白1(HMGB1)、Toll样受体4(TLR4)和核因子κB(NF-κB)水平的差异，记录用药期间不良反应发生情况。结果：观察组患者的疗效分级优于对照组，总有效率(100%

60/60)明显高于对照组(93.33%

56/60)

差异均有统计学意义(P<0.05)。观察组患者治疗后的中医证候总积分明显低于对照组，6 min步行试验距离明显长于对照组，血清HMGB1、TLR4和NF-κB水平明显低于对照组，差异均有统计学意义(P<0.05)。治疗期间，两组患者均未出现明显药物相关不良反应。结论：丹红注射液可有效优化慢性心力衰竭患者的治疗效果，具体机制可能与其调节HMGB1/TLR4/NF-κB通路相关。

Abstract

OBJECTIVE: To probe into the short-term efficacy and possible mechanism of Danhong injection combined with conventional therapy in patients with chronic heart failure. METHODS: A total of 120 patients with chronic heart failure admitted into this hospital from Jun. 2018 to Jun. 2020 were extracted to be divided into the control group and the observation group via the random number table

with 60 cases in each group. The control group received conventional western medicine treatment

while the observation group was treated with Danhong injection on the basis of the control group. After treatment of 4 weeks

the short-term efficacy

total traditional Chinese medicine syndrome score

6-min walking test distance

and serum levels of high mobility group protein 1（HMGB1）

Toll-like receptor 4（TLR4） and nuclear factor κB（NF-κB） were compared between two groups. The occurrence of adverse drugs reactions was recorded. RESULTS: The efficacy classification in the observation group was better than that in the control group

and the total effective rate（100%

60/60） was significantly higher than that in the control group（93.33%

56/60）

the differences were statistically significant（P<0.05）. After treatment

the total traditional Chinese medicine syndrome scores in the observation group were significantly lower than those in the control group

the 6-min walking test distance was significantly longer than that in the control group

and the serum levels of HMGB1

TLR4 and NF-κB were significantly lower than those in the control group

with statistically significant difference（P<0.05）. During treatment

there were no obvious adverse drug reactions in two groups. CONCLUSIONS: Danhong injection can effectively optimize the therapeutic effects in patients with chronic heart failure

and the specific mechanism may be related to its regulation of HMGB1/TLR4/NF-κB pathway.

关键词

慢性心力衰竭丹红注射液近期疗效HMGB1/TLR4/NF-κB通路

Keywords

Chronic heart failureDanhong injectionShort-term efficacyHMGB1/TLR4/NF-κB pathway

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