Clinical Efficacy of Tianchan Capsules Combined with Oxycodone Hydrochloride Sustained Release Tablets in the Treatment of Cancer Pain of Advanced Gastric Cancer and Its Effect on Quality of Life

WANG Yu; DONG Ming

doi:10.14009/j.issn.1672-2124.2022.02.012

您当前的位置：

首页 >

文章列表页 >

Clinical Efficacy of Tianchan Capsules Combined with Oxycodone Hydrochloride Sustained Release Tablets in the Treatment of Cancer Pain of Advanced Gastric Cancer and Its Effect on Quality of Life

更新时间：2022-10-08

- Clinical Efficacy of Tianchan Capsules Combined with Oxycodone Hydrochloride Sustained Release Tablets in the Treatment of Cancer Pain of Advanced Gastric Cancer and Its Effect on Quality of Life
- Vol. 22, Issue 2, Pages: 172-175(2022)
- 作者机构：
  
  1. 秦皇岛军工医院普外科
  2. 秦皇岛市第四医院肿瘤科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.02.012
  CLC： R735.2
- Published：2022，
扫描看全文
WANG Yu, DONG Ming. Clinical Efficacy of Tianchan Capsules Combined with Oxycodone Hydrochloride Sustained Release Tablets in the Treatment of Cancer Pain of Advanced Gastric Cancer and Its Effect on Quality of Life. [J]. 22(2):172-175(2022)
DOI：

WANG Yu, DONG Ming. Clinical Efficacy of Tianchan Capsules Combined with Oxycodone Hydrochloride Sustained Release Tablets in the Treatment of Cancer Pain of Advanced Gastric Cancer and Its Effect on Quality of Life. [J]. 22(2):172-175(2022) DOI： 10.14009/j.issn.1672-2124.2022.02.012.

摘要

目的：探讨天蟾胶囊联合盐酸羟考酮缓释片治疗晚期胃癌癌性疼痛的临床疗效及对患者生活质量的影响。方法：按照随机数字法，将2017年2月至2021年2月秦皇岛军工医院收治的113例晚期胃癌伴有癌性疼痛的患者分为联合组(56例)和对照组(57例)。对照组患者给予盐酸羟考酮缓释片治疗，联合组患者在对照组的基础上给予天蟾胶囊治疗。比较两组患者临床疗效、癌性疼痛情况、不良反应发生情况和治疗前后的生活质量。结果：联合组患者的镇痛有效率为94.64%(53/56)

明显优于对照组的77.19%(44/57)

差异有统计学意义(P<0.05)。治疗后，联合组与对照组患者的VAS评分均较治疗前明显降低，且与对照组比较，联合组患者的VAS评分更低，差异均有统计学意义(P<0.05)。治疗后，联合组与对照组患者的躯体功能、心理功能、社会功能和物质生活评分均较治疗前明显升高，且与对照组比较，联合组患者的躯体功能、心理功能、社会功能和物质生活评分更高，差异均有统计学意义(P<0.05)。联合组患者胃肠道反应、骨髓抑制、肝功能受损以及周围神经毒性等不良反应的发生率为16.07%(9/56)

与对照组[24.56%(14/57)]比较，差异无统计学意义(P>0.05)。结论：天蟾胶囊联合盐酸羟考酮缓释片治疗晚期胃癌癌性疼痛的临床疗效显著，不但能够有效降低患者癌性疼痛强度，还可改善患者的生活质量，同时安全性较好。

Abstract

OBJECTIVE: To probe into the clinical efficacy of Tianchan capsules combined with Oxycodone hydrochloride sustained release tablets in the treatment of cancer pain of advanced gastric cancer and its effect on quality of life. METHODS: Totally 113 patients with advanced gastric cancer complicated with cancer pain admitted into Qinhuangdao Jungong Hospital from Feb. 2017 to Feb. 2021 were divided into combined group（56 cases） and control group（57 cases） via random number table

the control group was treated with Oxycodone hydrochloride sustained release tablets

while the combined group was given Tianchan capsules based on the control group. The clinical efficacy

cancer pain

incidences of adverse drug reactions and quality of life before and after treatment were compared between two groups. RESULTS: The effective rate of analgesia of combined group was 94.64%（53/56）

significantly better than that of the control group（77.19%

44/57）

with statistically significant difference（P<0.05）. After treatment

the VAS scores of both groups were significantly lower than before treatment

and the VAS score of the combined group was significantly lower than that of the control group

with statistically significant differences（P<0.05）. After treatment

the scores of physical function

mental function

social function and material life of both groups were significantly higher than before treatment

and scores of physical function

mental function

social function and material life of combined group were significantly higher than those of the control group

with statistically significant differences（P<0.05）. The incidences of adverse drug reactions such as gastrointestinal reaction

myelosuppression

liver function damage and peripheral neurotoxicity in the combined group was 16.07%（9/56）

which had no statistical significance in comparison with 24.56%（14/57）in the control group（P>0.05）. CONCLUSIONS: The clinical efficacy of Tianchan capsules combined with Oxycodone hydrochloride sustained release tablets in the treatment of cancer pain of advanced gastric cancer is remarkable

which can not only effectively relieve cancer cancer pain

but also improve quality of life

with higher safety.

关键词

天蟾胶囊盐酸羟考酮缓释片晚期胃癌癌性疼痛疗效生活质量

Keywords

Tianchan capsulesOxycodone hydrochloride sustained release tabletsAdvanced gastric cancerCancer painEfficacyQuality of life

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Efficacy of Tranexamic Acid in the Treatment of Seborrheic Keratosis and its Effects on Patients’ Quality of Life

Blood Trough Concentration Monitoring and Efficacy of Vancomycin in the Treatment of Methicillin-Resistant Staphylococcus aureus Infection

Efficacy of Huaiqihuang Granules in the Adjuvant Treatment of Lupus Nephritis and Its Effects on Serum Ferritin

Prognosis and Safety of Programmed Death 1 Inhibitors in First-Line Treatment of Advanced Non-Small Cell Lung Cancer

Efficacy and Safety of Apatinib Mesylate Combined with Etoposide in the Treatment of Platinum-Resistant Recurrent Ovarian Cancer

Related Author

李筱琴

蔡艳丽

李媚

朱星艳

裴姣淼

LIU Yunning

LI Xiaofeng

TANG Jianhua

Related Institution

Xijing Hospital

Dept.of Pharmacy, the First Affiliated Hospital of Hebei North University

Dept.of Microbiology, the First Affiliated Hospital of Hebei North University

Dept.of Integrated Chinese and Western Medicine, Liyuan Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology

Dept. of Oncology, Huangshan People’s Hospital

⁰