OBJECTIVE: To probe into the application rationality of tigecycline for injection in inpatients in a tertiary rehabilitation hospital based on clinical-rehabilitation dual pathway management

so as to provide references for clinical rational medication. METHODS: Retrospectively analysis was conducted on the medical records of 99 patients using tigecycline for injection who were consulted at rehabilitation pharmacy center in this hospital from Jan. 2018 to May 2021

patients ’ general information

pathogenic examination

drug sensitivity test

medication rationality

clinical efficacy and incidence of adverse drug reactions were analyzed. RESULTS: The patients using tigecycline for injection in this hospital was mostly elderly male

and the overall number of patients was increasing year by year.Among the 99 patients

84 cases underwent pathogenic examination

and the delivery specimens were mainly sputum;totally 132 case-times of pathogenic bacteria were detected

mainly were Klebsiella pneumoniae

Acinetobacter baumannii and Pseudomonas aeruginosa

all of which showed high drug resistance; the clinical effective rate was78. 79%（ 78 cases）

and the incidence of adverse drug reactions was 5. 05%（ 5 cases）; the usage and dosage

route of administration and drug combination were all reasonable; 2 cases（ 2. 02%） were basically reasonable

mainly for empirical medication; 20 cases（ 20. 20%） were irrational medication

mainly for unreasonable indications and medication regimen. CONCLUSIONS: The clinical treatment effect of tigecycline for injection is good

with few adverse drug reactions. The main types of irrational drug application in this hospital are improper indications and medication regimen

the clinic should strengthen drug management

continuously carry out training on rational application of antibiotics to avoid drug abuse and improve the level of clinical rational drug application.