Application Rationality of Gabexate Mesilate in 328 Inpatients

WANG Weina; LI Jijia; GUO Heng; SHEN Su

doi:10.14009/j.issn.1672-2124.2022.01.018

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Application Rationality of Gabexate Mesilate in 328 Inpatients

更新时间：2022-10-08

- Application Rationality of Gabexate Mesilate in 328 Inpatients
- Vol. 22, Issue 1, Pages: 89-92(2022)
- 作者机构：
  
  首都医科大学附属北京友谊医院药学部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2022.01.018
  CLC： R969.3
- Published：2022，
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WANG Weina, LI Jijia, GUO Heng, et al. Application Rationality of Gabexate Mesilate in 328 Inpatients. [J]. 22(1):89-92(2022)
DOI：

WANG Weina, LI Jijia, GUO Heng, et al. Application Rationality of Gabexate Mesilate in 328 Inpatients. [J]. 22(1):89-92(2022) DOI： 10.14009/j.issn.1672-2124.2022.01.018.

摘要

目的:调查该院住院患者甲磺酸加贝酯的使用情况

并评价用药合理性。方法:调取2019—2020年该院328例使用甲磺酸加贝酯的住院患者病历

收集患者基本信息、住院信息和用药信息等

根据国内外指南和文献对用药合理性进行评价;从中筛选出诊断为急性胰腺炎的非手术患者286例

初步探讨甲磺酸加贝酯不同给药方案对治疗结局的影响。结果:328例使用甲磺酸加贝酯的住院患者中

超说明书适应证用药22例(占6.71%)

均为手术患者;溶剂不适宜94例(占28.66%)

93例使用0.9%氯化钠注射液作为溶剂

1例使用10%葡萄糖注射液作为溶剂;滴注速度过快7例(占2.13%)

其滴注速度>2.5 mg/(kg·h);与乌司他丁联合应用161例(占49.09%)。是否联合乌司他丁、不同给药疗程(≤5 d和>6 d)对患者的实验室指标、腹痛缓解时间和住院时间均无显著影响(P>0.05)。结论:甲磺酸加贝酯的临床应用尚存在不足

临床应予以高度重视

促进合理用药。

Abstract

OBJECTIVE: To investigate the application of gabexate mesilate in inpatients from this hospital

so as to evaluate its rationality. METHODS: Medical records of 328 inpatients using gabexate mesilate in this hospital during2019-2020 were acquired

patients’ general information

hospitalization information and medication information were collected

the medication rationality was evaluated according to domestic and overseas guidelines and literature; totally 286 non-surgical patients diagnosed with acute pancreatitis were screened out

effects of different dosage regimens of gabexate mesylate on the treatment outcomes were preliminarily discussed. RESULTS: Among the 328 inpatients using gabexate mesilate

22 cases（ 6. 71%） were off-label and over-indication medication

all of them were surgical patients; 94 cases（ 28. 66%） were inappropriate solvents

93 cases used 0. 9% sodium chloride injection as the solvent and 1 case used10% dextrose injection as the solvent; 7 cases（ 2. 13%） were over-fast infusion speed

which was >2. 5 mg/（ kg·h）;161 cases（ 49. 09%） were combined application with ulinastatin. The combined application of ulinastatin and the different dosage regimens（ ≤5 d and >6 d） did not have significant effects on laboratory indicators

remission time of abdominal pain and length of hospital stay（ P>0. 05）. CONCLUSIONS: The clinical application of gabexate mesylate is still inadequate

and the clinic should pay close attention to promote its rational application.

关键词

甲磺酸加贝酯急性胰腺炎临床用药合理性分析

Keywords

Gabexate mesilateAcute pancreatitisClinical medicationRationality analysis

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