OBJECTIVE: To probe into the clinical efficacy of modified Buzhong Yiqi decoction combined with Rabeprazole sodium enteric-coated capsules and Mosapride citrate dispersible tablets in the treatment of reflux esophagitis and its effects on clinical symptoms and life quality. METHODS: Totally 92 patients with reflux esophagitis admitted into this hospital from Sept. 2019 to Sept. 2020 were divided into two groups via the random number table.The control group（ 46 cases） was treated with Rabeprazole sodium enteric-coated capsules and Mosapride citrate dispersible tablets

while the observation group（ 46 cases） was given modified Buzhong Yiqi decoction based on the control group

both groups were continuously treated for 8 weeks. Changes of gastrointestinal hormone levels

oxidative stress indicators of esophageal mucosal tissue

TCM syndrome integrals and scores of life quality before and after 8 weeks of treatment in the two groups were observed

the clinical efficacy and incidences of adverse drug reactions were analyzed. RESULTS: The total effective rate of observation group was 95. 65%（ 44/46）

which was higher than that of the control group（ 80. 43%

37/46）

with statistically significant difference（ P < 0. 05）. Compared with before treatment

the serum motilin

gastrin and total superoxide dismutase of esophageal mucosal tissue in both groups were increased

the general score of short form 36 health survey

physical health score and mental health score were increased

the nitric oxide and malondialdehyde levels of esophageal mucosal tissue were decreased

various TCM syndrome integrals（ chest distension

heat burn

hiccup singultation and emotion depression） were decreased; the above indicators and scores were significantly better in the observation group than in the control group

with statistically significant difference（ P<0. 05）. The incidences of adverse drug reactions of observation group and control group were respectively 10. 87%（ 5/46） and 8. 70%（ 4/46）

the difference was not statistically significant（ P > 0. 05）.CONCLUSIONS: The clinical efficacy of modified Buzhong Yiqi decoction combined with Rabeprazole sodium entericcoated capsules and Mosapride citrate dispersible tablets in the treatment of reflux esophagitis is remarkable

which can effectively relieve various clinical symptoms

improve gastrointestinal hormone levels oxidative stress of esophageal mucosal tissue

promote patients’ life quality

with few adverse drug reactions.