OBJECTIVE: To probe into the correlation between types and age factors of premature ejaculation and clinical efficacy of dapoxetine hydrochloride. METHODS: Totally 96 patients with premature ejaculation admitted into reproductive medicine department of First Hospital of Qinhuangdao from Oct. 2018 to Jan. 2020 were extracted to be divided into 42 cases in the primary group（ primary premature ejaculation） and 54 cases in the secondary group（ secondary premature ejaculation） according to different types of premature ejaculation. According to age

the patients were divided into 46 cases in the young group（ <35 years） and 50 cases in the middle-aged group（ ≥35 years）. All patents were given dapoxetine hydrochloride 30 mg orally from 1 h to 3 h before sex behavior

and all patients received continuous treatment for 2 months and followed up one month after drug withdrawal. The intravaginal ejaculation latency period（ IELT）

premature ejaculation diagnostic criteria scale（ PEDT） score

premature ejaculation analysis scale（ PEP） score

clinical efficacy and recurrence of patients in each group before and after treatment were observed.RESULTS:（ 1） IELT and PEDT scores in the primary group and the secondary group were significantly improved after treatment and at the end of follow-up compared with those before treatment

and IELT scores in the secondary group were significantly longer than those in the primary group after treatment and at the end of follow-up

while PEDT scores were significantly lower than those in the primary group

with statistically significant difference（ P<0. 05）. PEP scores of two groups after treatment and at the end of follow-up were significantly improved compared with those before treatment

the difference was statistically significant（ P<0. 05）. After treatment and at the end of follow-up

patients in the secondary group had significantly higher ejaculatory control and sexual satisfaction scores than those in the primary group

while the scores of premature ejaculation-related distress and impacts of premature ejaculation on partner relationship were significantly lower than those in the primary group

with statistically significant difference（ P<0. 05）.（ 2） IELT and PEDT scores of the young group and the middle-aged group were significantly improved after treatment and at the end of follow-up compared with those before treatment

and IELT of the young group were significantly longer than those of the middle-aged group

while PEDT scores were significantly lower than those of the middle-aged group

with statistically significant difference（ P < 0. 05）. PEP scores of two groups after treatment and at the end of follow-up were significantly improved compared with those before treatment

with statistically significant difference（ P<0. 05）. After treatment

the scores of ejaculation control ability in the young group were significantly higher than those in the middle-aged group

while the scores of premature ejaculation-related distress and impacts of premature ejaculation on partner relationship were significantly lower than those in the middle-aged group. At the end of followup

the scores of premature ejaculation-related distress and impacts of premature ejaculation on partner relationship in the young group were significantly lower than those in the middle-aged group

with statistically significant difference（ P<0. 05）.（ 3） The total effective rates in the primary group and the secondary group were respectively 71. 43%（ 30/42） and88. 89%（ 48/54）

and the recurrence rates were respectively 30. 95%（ 13/42） and 9. 26%（ 5/54）

the differences were statistically significant（ P < 0. 05）. The total effective rates of the young group and the middle-aged group were respectively 89. 13%（ 41/46） and 72. 00%（ 36/50）

the difference was statistically significant（ P < 0. 05）; and the recurrence rates were respectively 17. 39%（ 8/46） and 20. 00%（ 10/50）

with no statistically significant difference（ P>0. 05）. CONCLUSIONS: The clinical efficacy of dapoxetine hydrochloride in the treatment of secondary premature ejaculation is better than that of primary premature ejaculation

and the clinical effects of dapoxetine hydrochloride in the treatment of young patients with premature ejaculation is better than that of middle-aged patients.