Analysis on 1 167 Reports of Adverse Drug Reactions in Shanghai Fifth People’s Hospital,Fudan University from 2017 to 2020

QIAN Wei; ZHANG Xiuling; SUN Guangchun; SONG Jinfei

doi:10.14009/j.issn.1672-2124.2021.12.025

您当前的位置：

首页 >

文章列表页 >

Analysis on 1 167 Reports of Adverse Drug Reactions in Shanghai Fifth People’s Hospital,Fudan University from 2017 to 2020

更新时间：2022-10-08

- Analysis on 1 167 Reports of Adverse Drug Reactions in Shanghai Fifth People’s Hospital,Fudan University from 2017 to 2020
- Vol. 21, Issue 12, Pages: 1533-1536(2021)
- 作者机构：
  
  复旦大学附属上海市第五人民医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.12.025
  CLC： R95
- Published：2021，
扫描看全文
QIAN Wei, ZHANG Xiuling, SUN Guangchun, et al. Analysis on 1 167 Reports of Adverse Drug Reactions in Shanghai Fifth People’s Hospital,Fudan University from 2017 to 2020. [J]. 21(12):1533-1536(2021)
DOI：

QIAN Wei, ZHANG Xiuling, SUN Guangchun, et al. Analysis on 1 167 Reports of Adverse Drug Reactions in Shanghai Fifth People’s Hospital,Fudan University from 2017 to 2020. [J]. 21(12):1533-1536(2021) DOI： 10.14009/j.issn.1672-2124.2021.12.025.

摘要

目的:基于复旦大学附属上海市第五人民医院(以下简称"我院")的药品不良反应(adverse drug reaction

ADR)数据

了解ADR发生规律和特点

促进临床合理用药。方法:选取2017—2020年我院收集上报的1 167例ADR报告

从患者年龄、性别

ADR涉及的药物种类、累及器官和(或)系统、给药途径、因果关系及报告人职业等方面进行回顾性分析。结果:1 167例ADR报告中

药师上报的ADR最多(779例

占66.75%);发生ADR的女性患者所占比例(651例

占55.78%)略高于男性患者(516例

占44.22%);> 60岁患者共621例

占53.21%;口服给药所致ADR最多

共580例(占49.70%)

其次为静脉滴注(502例

占43.02%);引发ADR的药物有364种

其中抗感染药引起的ADR为395例(占33.85%)

涉及39种抗感染药

氟喹诺酮类、头孢菌素类和大环内酯类抗菌药物引发的ADR最为常见; ADR的临床表现主要为消化系统损害(396例

占33.93%)、皮肤及其附件损害(284例

占24.34%)。结论:我院应继续加强ADR监测工作

关注老年人用药安全

合理选择药物和给药途径

以避免或减少ADR的发生。

Abstract

OBJECTIVE: To investigate the occurrence regularity and characteristics of adverse drug reactions（ ADR）based on the data of ADR in Shanghai Fifth People ’s Hospital

Fudan University（ hereinafter referred to as “our hospital”）

so as to to promote the rational application of clinical drugs. METHODS: Totally 1 167 reports of ADR collected and reported by our hospital from 2017 to 2020 were retrospectively analyzed in terms of patients’ age and gender

types of drugs involved in ADR

organs and（ or） systems involved

route of administration

causality and occupation of the reporter. RESULTS: Among 1 167 ADR cases

the highest number of ADR were reported by pharmacists（ 779 cases

66. 75%）. The proportion of female patients with ADR（ 651 cases

55. 78%） was slightly higher than that of male patients（ 516 cases

44. 22%）. A total of 621 patients were over 60 years

accounting for 53. 21%.The main route of administration was oral administration（ 580 cases

49. 70%）

followed by intravenous administration（ 502 cases

43. 02%）. There were 364 kinds of drugs that caused ADR

among which 395 cases（ 33. 85%） were caused by anti-infective drugs

including 39 kinds of anti-infective drugs

with fluoroquinolones

cephalosporins and macrolides as the most common antibiotics that caused ADR. The clinical manifestations of ADR were mainly digestive system damage（ 396 cases

33. 93%） and skin and accessory damage（ 284 cases

24. 34%）. CONCLUSIONS: Our hospital should continue to strengthen the monitoring of ADR

pay attention to the safety of medication for the elderly

and rationally select drugs and routes of administration in order to avoid or reduce the occurrence of ADR.

关键词

药品不良反应临床表现抗感染药分析

Keywords

Adverse drug reactionsClinical manifestationsAnti-infective drugsAnalysis

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Analysis of Literature on Case Reports of Adverse Drug Reactions Induced by Montelukast Sodium in Children

Comparative Analysis on Adverse Drug Reactions of Domestic and Imported Iodixanol Injection

Comparative Analysis on Adverse Drug Reactions Between Ibuprofen and Acetaminophen

Domestic and Foreign Literature of Adverse Drug Reactions Induced by Tigecycline

Literature Analysis of Hemophagocytic Lymphohistiocytosis Induced by Antiepileptic Drugs

Related Author

LIU Xiaohui

YU Boran

TIAN Chao

CHENG Haixin

ZHAO Libo

WANG Xiaoling

TIAN Lei

HUANG Lei

Related Institution

Dept.of Pharmacy, Children’s Hospital, Capital Institute of Pediatrics

Dept.of Pharmacy, Beijing Children’s Hospital, Capital Medical University,National Center for Children’s Health

Dept. of Pharmacy, Jiangsu Province Hospital of Chinese Medicine

Institution of National Drug Clinical Trails, the Affiliated Hospital of Xuzhou Medical University

School of Pharmacy, Nanjing Medical University

⁰