OBJECTIVE: To systematically evaluate the effects of mobile health care management on medication compliance of patients with hypertension. METHODS: PubMed

CNKI and Wanfang Data were retrieved to collect the randomized controlled trials of effects of mobile health care management on medication compliance of patients with hypertension（ the control group was treated with conventional medication treatment + nursing care management

while the study group received intervention of mobile health care management on the basis of routine management of the control group）. After literature screening according to the research objectives

literature quality was evaluated

and Meta-analysis was performed by using RevMan 5. 3 software. RESULTS: Totally 12 articles were enrolled

including2 371 patients（ 1 184 patients in the study group and 1 187 patients in the control group）. Meta-analysis showed that compared with the conventional management

after the application of mobile health care management methods

the medication compliance scores of patients with hypertension were significantly improved

and the difference was statistically significant（ SMD = 0. 76

95% CI = 0. 51-1. 00

P < 0. 000 01）. Compared with the conventional management

the application of mobile health care management could effectively improve the medication compliance scores for 3 months（ SMD = 0. 94

95% CI = 0. 19-1. 68

P = 0. 01）

and the medication compliance scores remained at the high level for 12 months（ SMD = 0. 96

95% CI = 0. 40-1. 51

P = 0. 000 7）

the differences were statistically significant. The most significant reduction in systolic pressure was observed at 3 months of mobile health care management application[MD =-7. 63 mm Hg（ 1 mm Hg = 0. 133 kPa）

95% CI =-12. 39--2. 86

P = 0. 002]

and the patients still had significantly lower systolic pressure at 6 months（ MD =-5. 55 mm Hg

95% CI =-7. 68--3. 42

P < 0. 000 01）（ but the magnitude was less than at 3 months）

the differences were statistically significant compared with the conventional management. Patients showed the most significant reduction in diastolic pressure at 6 months of mobile health care management application

with statistically significant difference compared with the conventional management（ MD =-3. 36 mm Hg

95% CI =-5. 11--1. 62

P = 0. 000 2）. And the downward trend of blood pressure continued to 12 months. CONCLUSIONS: Mobile health care has natural advantages in the treatment and management of chronic diseases such as hypertension

and could play an important role in medical services in the future.