OBJECTIVE: To probe into the effects of Yiqi Jiedu Huoluo formula on improvement of renal tubule damage

the phosphorylation of c-Jun N-terminal kinase（ p-JNK）

immunoglobulin G4（ IgG4） and β2 microglobulin（ β2-MG） in peripheral bloodmononuclear cells of patients with early diabetic nephropathy. METHODS: Totally 106 patients（ 41 outpatients and 65 inpatients） with early diabetic nephropathy admitted into Jinchang People’s Hospital from Oct. 2018 to Jan. 2020 were extracted to be divided into the observation group and the control group. All patients were given basic treatments such as lifestyle intervention

and 53 patients in the control group were given symptomatic treatment to control the blood glucose

blood pressure and correct dyslipidemia

while 53 patients in the observation group received Yiqi Jiedu Huoluo formula on the basis of the control group. Clinical efficacy

fasting blood glucose（ FBG）

glycosylated hemoglobin（ HbA

1

c） and creatinine（ CREA） levels

peripheral blood mononuclear cell P-JNK

IgG4

β2-Mg

kidney injury molecule1（ KIM-1）

neutrophil gelatinase-associated lipid carrier protein（ NGAL）

24 h urinary protein quantization（ 24 hPRO） and urinary microalbumin（ m Alb） levels before and after treatment in two groups were observed. RESULTS: After treatment

the levels of FBG

HbA

1

c

24 hPRO and m Alb of two groups were significantly lower than those before treatment

and the observation group was significantly lower than the control group

with statistically significant differences（ P

<

0. 05）. After treatment

the urine KIM-1

NGAL

IgG4

β2-MG and peripheral blood mononuclear cells p-JNK of two groups were significantly lower than those before treatment

and the observation group was significantly lower than the control group

with statistically significant differences（ P

<

0. 05）. After treatment

the scores of traditional Chinese medicine syndrome in both groups were significantly lower than those before treatment

and the observation group was significantly lower than the control group

with statistically significant differences（ P

<

0. 05）. The total effective rate of the observation group was 94. 34%（ 50/53）

significantly better than 77. 47%（ 40/53） of the control group

the difference was statistically significant（ P

<

0. 05）.CONCLUSIONS: Yiqi Jiedu Huoluo formula in the treatment of early diabetic nephropathy can significantly improve the symptoms of patients

protect the kidney function and delay the progression of diabetic nephropathy. Its mechanism of action may be related to the intervention of ROS/JNK signaling pathway.