OBJECTIVE: To probe into the clinical efficacy of methylprednisolone sodium succinate combined with immunoglobulin in the treatment of severe infectious mononucleosis in children. METHODS: Totally 96 children with severe infectious mononucleosis admitted into Children’s Hospital of Hebei Province from Mar. 2018 to Jan. 2021 were selected and divided into control group and research group via random number table

with 48 cases in each group. The control group was given conventional therapy

while the research group was given methylprednisolone sodium succinate combined with immunoglobulin. The clinical efficacy

remission time of clinical symptoms

proportions of T lymphocyte subpopulation

serum biochemical indicators and incidences of adverse drug reactions of the two groups were observed.RESULTS: Compared with the total effective rate of 70. 83%（ 34/48） in the control group

that of the research group（ 93. 75%

45/48） was significantly higher

with statistically significant difference（ P

<

0. 05）. The research group had significantly lower CD8

+

and significantly higher CD3

+

CD4

+

and CD4

+

/CD8

+

than the control group after treatment

with statistically significant differences（ P

<

0. 05）. The C-reactive protein

while blood cell count

proportion of heterolymphocyte

alanine aminotransferase

creatine kinase isoenzyme and loading capacity of EB DNA of research group were significantly lower than those of the control group

with statistically significant differences（ P

<

0. 05）. The incidences of adverse drug reactions of research group and control group were respectively 16. 67%（ 8/48） and 8. 33%（ 4/48）

the difference was not statistically significant（ P

>

0. 05）. Compared with the control group

the remission times of angina

fever

hepatosplenomegaly and lymph gland of research group were significantly shorter

with statistically significant differences（ P

<

0. 05）. CONCLUSIONS: The combination of methylprednisolone sodium succinate and immunoglobulin in the treatment of severe infectious mononucleosis in children can promote the symptom improvement and immunological function

improve serum biochemical indicators

safe and reliable.