Progress of Pharmacological Effects and Mechanism of Hepatic and Renal Damage of Isopsoralen

YANG Kuo; GAO Rong; SHEN Baode; HANG Lingyu; MA Yazhong; YUAN Hailong

doi:10.14009/j.issn.1672-2124.2021.11.027

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Progress of Pharmacological Effects and Mechanism of Hepatic and Renal Damage of Isopsoralen

更新时间：2022-10-08

- Progress of Pharmacological Effects and Mechanism of Hepatic and Renal Damage of Isopsoralen
- Vol. 21, Issue 11, Pages: 1399-1403(2021)
- 作者机构：
  
  1. 空军特色医学中心药剂科
  2. 江西中医药大学药学院
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.11.027
  CLC： R285
- Published：2021，
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YANG Kuo, GAO Rong, SHEN Baode, et al. Progress of Pharmacological Effects and Mechanism of Hepatic and Renal Damage of Isopsoralen. [J]. 21(11):1399-1403(2021)
DOI：

YANG Kuo, GAO Rong, SHEN Baode, et al. Progress of Pharmacological Effects and Mechanism of Hepatic and Renal Damage of Isopsoralen. [J]. 21(11):1399-1403(2021) DOI： 10.14009/j.issn.1672-2124.2021.11.027.

摘要

补骨脂是临床常用中药

具有补肾壮阳、固精缩尿的功效。伴随中药补骨脂及其复方制剂使用过程中引起肝脏不良反应的报道日益增多

补骨脂的肝毒性物质基础问题也受到学者的广泛关注。异补骨脂素是中药补骨脂中的主要药效成分和毒性成分。本文主要从药理作用和肝肾毒性2个方面

对2010年至今国内外学者关于异补骨脂素的研究进行综述

为异补骨脂素的新药研究和安全用药提供理论依据。

Abstract

Psoralea corylifolia is a kind of commonly used traditional Chinese medicine in clinic

which has the effects of tonifying kidney and strengthening Yang

securing essence and reducing urination. Along with the increasing reports of hepatic adverse drug reactions induced by the use of traditional Chinese medicine isopsoralen and its compound preparations

the issue of hepatotoxic substance basis of isopsoralen has also been widely concerned by scholars. Isopsoralen is the main active and toxic component of psoralea corylifolia. This thesis mainly reviews the research on isopsoralen by domestic and foreign scholars from 2010 to now

so as to provide theoretical basis for new drug research and safe use of isopsoralen.

关键词

异补骨脂素药理作用肝毒性肾毒性作用机制

Keywords

IsopsoralenPharmacological effectsHepatotoxicityNephrotoxicityMechanism

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