OBJECTIVE: To rapidly evaluate the efficacy

safety and economical efficiency of Xingnaojing injection in the treatment of stroke

so as to provide evidence-based reference for clinical rational medication.METHODS: WanFang database

CNKI

CBM

Embase

PubMed and the Cochrane Library were searched

health technology assessment reports

systematic reviews/Meta-analyses and pharmacoeconomic studies related to Xingnaojing injection in the treatment of stroke were enrolled. The included data were analyzed and summarized

and quality evaluation was performed on the literature and its methodology. RESULTS: A total of 28 studies were involved

of which 21 were systematic evaluations/Meta-analyses

7 were pharmacoeconomic studies

no health technology assessment reports were retrieved. The result showed that Xingnaojing injection combined with conventional regimens in the treatment of stroke can improved patients’ clinical symptoms by inhibiting the cascade reaction after cerebral hemorrhage and reduced the mortality in patients with cerebral hemorrhage; it also had significant advantages in improving the living capability index of stroke patients

promoting the scores of National Institutes of Health Stroke Scale and European Stroke Scale

improving the neurological deficits and coma level in patients with stroke combined with impaired consciousness

reducing volume of cephalophyma and improving various hemorheological indicators;however

it had no significant effect on the cure rate of patients; meanwhile

there were no serious adverse drug reactions occurred during treatment

which had good safety. CONCLUSIONS: Xingnaojing injection has good efficacy and safety in the treatment of stroke. In the future

more in-depth pharmacoeconomic studies and more standardized clinical observation studies can be conducted to supplement the relevant economic evaluation evidence.