Effects of Doxepin Combined with Escitalopram on Levels of Glial Cell-Derived Neurotrophic Factor and 5-Hydroxytryptamine in Patients with Depression

ZHANG Xiuqiong; LIN Yin; LIANG Yongqing; CHEN Shengbai

doi:10.14009/j.issn.1672-2124.2021.11.014

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Effects of Doxepin Combined with Escitalopram on Levels of Glial Cell-Derived Neurotrophic Factor and 5-Hydroxytryptamine in Patients with Depression

更新时间：2022-10-08

- Effects of Doxepin Combined with Escitalopram on Levels of Glial Cell-Derived Neurotrophic Factor and 5-Hydroxytryptamine in Patients with Depression
- Vol. 21, Issue 11, Pages: 1344-1347(2021)
- 作者机构：
  
  1. 海南省安宁医院精神康复科
  2. 海南省安宁医院心理咨询与治疗中心
  3. 海南省安宁医院物质依赖科
  4. 海南省平山医院精神科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.11.014
  CLC： R749.4
- Published：2021，
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ZHANG Xiuqiong, LIN Yin, LIANG Yongqing, et al. Effects of Doxepin Combined with Escitalopram on Levels of Glial Cell-Derived Neurotrophic Factor and 5-Hydroxytryptamine in Patients with Depression. [J]. 21(11):1344-1347(2021)
DOI：

ZHANG Xiuqiong, LIN Yin, LIANG Yongqing, et al. Effects of Doxepin Combined with Escitalopram on Levels of Glial Cell-Derived Neurotrophic Factor and 5-Hydroxytryptamine in Patients with Depression. [J]. 21(11):1344-1347(2021) DOI： 10.14009/j.issn.1672-2124.2021.11.014.

摘要

目的:探讨多塞平联合艾司西酞普兰对抑郁症患者胶质细胞源性神经营养因子(GDNF)、5-羟色胺(5-HT)水平的影响。方法:选取2017年8月至2019年8月于海南省安宁医院接受治疗的抑郁症患者123例

按照随机数字表法分为西酞普兰组61例、联合治疗组62例。西酞普兰组患者采用艾司西酞普兰治疗

联合治疗组患者采用多塞平联合艾司西酞普兰治疗。采用汉密尔顿抑郁量表(hamilton depression scale

HAMD)评价患者心理抑郁情况

采用匹兹堡睡眠质量指数(Pittsburgh sleep quality index

PSQI)评价患者睡眠质量

采用成人自杀意念问卷(adult suicidal Ideation questionnaire

ASIQ)对患者自杀意念进行评价。采用免疫透射比浊法检测患者GDNF、5-HT水平

采用酶标分析仪检测白细胞介素(IL) 2、IL-22、IL-1β、总抗氧化能力(TAOC)、8-羟基脱氧鸟苷(8-OHdG)和过氧化氢酶(CAT)水平

采用流式细胞仪检测T淋巴细胞亚群水平。观察两组患者的治疗效果。结果:治疗后

与西酞普兰组比较

联合治疗组患者的HAMD评分、PSQI评分和ASIQ评分明显较低

差异均有统计学意义(P <0.05)。治疗后

与西酞普兰组比较

联合治疗组患者的GDNF、5-HT、CAT、CD4~+和CD3~+水平明显较高

IL-2、IL-22、IL-1β、TAOC、8-OHdG和CD8~+水平明显较低

差异均有统计学意义(P <0.05)。联合治疗组患者的总有效率为95.16%(59/62)

明显高于西酞普兰组的83.61%(51/61)

差异有统计学意义(P <0.05)。结论:多塞平联合艾司西酞普兰治疗抑郁症

可明显改善患者的抑郁情绪、睡眠质量和自杀意念

调控GDNF、5-HT水平

减轻炎症反应

改善患者抗氧化能力

治疗效果显著。

Abstract

OBJECTIVE: To explore the effects of doxepin combined with escitalopram on levels of glial cellderived neurotrophic factor（ GDNF） and 5-hydroxytryptamine（ 5-HT） in patients with depression. METHODS:Totally 123 patients admitted into Hainan Provincial Anning Hospital from Aug. 2017 to Aug. 2019 were extracted to be divided into the citalopram group（ n = 61） and the combined treatment group（ n = 62） via the random number table. The citalopram group was treated with escitalopram

while the combined treatment group received doxepin combined with escitalopram. Hamilton depression scale（ HAMD） was used to evaluate the psychological depression of patients. Pittsburgh sleep quality index（ PSQI） was used to evaluate the sleep quality of patients. Adult suicidal ideation questionnaire（ ASIQ） was adopted to evaluate the suicidal ideation of patients. The levels of GDNF and 5-HT were detected by immunoturbidimetry. The levels of interleukin（ IL） 2

IL-22

IL-1β

total antioxidant capacity（ TAOC）

8-hydroxy-deoxyguanosine（ 8-OHDG） and catalase（ CAT） were detected by enzyme-linked immunosorbent assay. The levels of T lymphocyte subsets were detected by flow cytometry. The therapeutic effects of two groups were observed. RESULTS: After treatment

compared with the citalopram group

the scores of HAMD

PSQI and ASIQ in the combined treatment group were lower

with statistically significant differences（ P

0. 05）. After treatment

compared with the citalopram group

the levels of GDNF

5-HT

CAT

CD4

and CD3

in the combined treatment group were higher

and the levels of IL-2

IL-22

IL-1β

TAOC

8-OHdG and CD8

in the combined treatment group were lower

with statistically significant differences（ P

0. 05）. The total effective rate of the combined treatment group was 95. 16%（ 59/62）

significantly higher than 83. 61%（ 51/61） of the citalopram group

the difference was statistically significant（ P

0. 05）. CONCLUSIONS: The efficacy of doxepin combined with escitalopram in the treatment of depression is significant

which can effectively improve the depression

sleep quality and suicidal ideation of patients

regulate the levels of GDNF and 5-HT

reduce the inflammation

and improve the antioxidant capacity.

关键词

抑郁症多塞平艾司西酞普兰胶质细胞源性神经营养因子5-羟色胺

Keywords

DepressionDoxepinEscitalopramGlial cell-derived neurotrophic factor5-hydroxytryptamine

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