OBJECTIVE: To probe into the clinical efficacy and safety of qi-tonifying and blood-invigorating method combined with western medicine conventional therapy in the treatment of qi-deficiency and blood-stasis type of acute ischemic stroke. METHODS: Totally 100 patients with acute ischemic stroke admitted into Shijiazhuang Hospital of Traditional Chinese Medical from Dec. 2020 to Feb. 2021 were selected and randomly divided into observation group and control group via SAS

with 50 cases in each group. The control group was given western medicine for conventional therapy according to medical guidelines for diagnose and treatment

while the observation group was given prescription of qi-tonifying and blood-invigorating based on the control group. The clinical efficacy

related indicators and incidences of adverse drug reactions of two groups were observed. RESULTS: The total effective rate of observation group was 88. 00%（44/50）

which was significantly higher than that of the control group（72. 00%

36/50）

with statistically significant difference（P<0. 05）. The NIHSS score

serum total cholesterol

triacylglycerol

low density lipoprotein cholesterol

fibrinogen

plasma viscosity

whole blood low-shear viscosity

whole blood medium-shear viscosity

whole blood high-shear viscosity

C-reactive protein

homocysteine levels of both groups after treatment were significantly lower than those of before treatment; and the above indicators of observation group were significantly lower than those of the control group

with statistically significant differences（P< 0. 05）. The high density lipoprotein cholesterol levels of both groups after treatment were significantly higher than those of before treatment

the plasma thrombin time

plasma prothrombin time and activated partial thrombin time of both groups had been significantly prolonged after treatment

the above indicators of observation group were significantly better than those of the control group

with statistically significant differences（P< 0. 05）. No adverse reactions occurred in both groups.CONCLUSIONS: The clinical efficacy of qi-tonifying and blood-invigorating method combined with western medicine conventional therapy in the treatment of qi-deficiency and blood-stasis type of acute ischemic stroke is remarkable

which can promote the recovery of neurological function

regulate lipid metabolism

improve coagulation function and blood flow

reduce C-reactive protein and homocysteine levels

with good safety and efficiency.