OBJECTIVE: To probe into the application status of probiotics in children with inflammatory bowel disease（ IBD） in outpatient and emergency department in Beijing Children’s Hospital and the Children’s Hospital

Capital Institute of Pediatrics（ hereinafter referred to as “two children’s hospitals”）

and to explore the application rationality of probiotics in IBD.METHODS: Retrospective analysis was performed to extract 516 prescriptions of IBD in outpatient and emergency department of two children’s hospitals from Aug.2019 to Jul.2020. Based on domestic and foreign guidelines

the rationality of preparations with probiotics was analyzed. RESULTS: There were 516 outpatient and emergency prescriptions in children with IBD

the consumption sum of drugs was 78 376. 03 yuan.And there were 147 prescriptions of probiotics

the consumption sum of probiotics was 12 980. 74 yuan.Probiotic preparations involved were respectively Clostridium butyricum bifidobacterium powder（ 68 prescriptions）

Compound eosinophil-lactobacillus tablets（ 42 prescriptions）

Bifidobacterium quadruplex（ 34 prescriptions）

Clostridium butyricum powder（ 14 prescriptions） and Saccharomyces boulardii powder（ 5 prescriptions）.There were 45 irrational prescriptions

and the consumption sum of irrational prescriptions was 5 166. 4 yuan. The irrational types were respectively improper selection of drugs（ 42 prescriptions） and inappropriate drug combination（ 3 prescriptions）. CONCLUSIONS: The application of probiotic preparations in children with IBD in the outpatient and emergency department is problematic and needs to be better managed to promote rational drug application.