OBJECTIVE: To investigate the clinical application characteristics of donepezil in inpatients

so as to provide reference for standardizing rational drug use in clinic. METHODS: A total of 170 inpatients with donepezil in People’s Hospital

Peking University from 2018 to 2019 were extracted for statistical analysis of the general conditions

clinical characteristics and drug combination. RESULTS: Among the 170 patients

91 were males and 79 were females

the average age was（ 78. 44±8. 67） years

the average length of stay was（ 12. 65±6. 93） d. There were 32 patients with previous allergic history. Totally 165 patients（ 97. 06%） had the diagnosis related to the administration of donepezil and 5 patients（ 2. 94%） lacked the corresponding diagnosis. The dosage of donepezil was mainly 5 mg

qd

and 10 mg

qd

149 cases in total

accounting for 87. 65%. And 12. 35% of patients（ 21 cases）might have inappropriate dosage. In some patients

donepezil was combined with citalopram

sertraline

paroxetine

risperidone

tolterodine and other drugs

which might lead to potential drug risks due to drug interactions. Meanwhile

7 patients（ 4. 12%） had adverse drug reactions. CONCLUSIONS: The use of donepezil in inpatients has irregular diagnosis

improper usage and dosage

and potential medication risks

which should attract clinical attention;meanwhile

pharmacists should pay attention to the phenomenon in pharmaceutical care.