OBJECTIVE: To probe into the clinical efficacy of Jiujiecha gargle combined with modified Yiwei decoction in the treatment of radiation-induced oral mucositis. METHODS: A total of 118 patients with head and neck cancer who developed radiation-induced oral mucositis in Qiannan Buyei and Miao Autonomous Prefecture Traditional Chinese Medicine Hospital from Mar. 2017 to Mar. 2020 were extracted to be divided into the observation group and the control group via the random number table

with 59 cases in each group. On the basis of conventional treatment

the control group was treated with compound chlorhexidine gargle

while the observation group received Jiujiecha gargle combined with modified Yiwei decoction. The clinical efficacy

numerical rating scale（ NRS） score for oropharyngeal pain before treatment and after treatment of 1 and 2 months（ treatment for 1 month and follow-up for 1 month）

levels of inflammatory factors

healing time

occurrence of fungal infection and occurrence of adverse blood reactions before and after treatment of 1 month in two groups were observed. RESULTS: The total effective rate of the observation group was 93. 22%（ 55/59）

significantly higher than 79. 66%（ 47/59） of the control group

the difference was statistically significant（ P<0. 05）. After treatment

the levels of transforming growth factor β1

tumor necrosis factor α

C-reactive protein and NRS score in two groups decreased significantly compared with before treatment

and the decrease in the observation group was greater than that in the control group

the differences were statistically significant（ P < 0. 05）.Compared with the control group

the healing time was shorter and the incidence of fungal infection was lower in the observation group

with statistically significant difference（ P<0. 05）. The incidence of leukopenia and lymphopenia of grade 3 and above in the observation group was lower than that in the control group

the differences were statistically significant（ P<0. 05）. CONCLUSIONS: Jiujiecha gargle combined with modified Yiwei decoction can effectively treat the radiation-induced oral mucositis

reduce the level of inflammatory factors

the incidence of fungal infection and adverse blood reactions

and improve pain of patients.