OBJECTIVE: To probe into the clinical efficacy of traditional Chinese medicine prescription combined with alendronate in the treatment of postmenopausal osteoporosis. METHODS: Totally 156 patients with postmenopausal osteoporosis admitted to Meizhou Hospital of Traditional Chinese Medicine from Jun. 2018 to Jun. 2020 were divided into the western medicine group（ n = 52）

traditional Chinese medicine group（ n = 52） and observation group（ n =52） according to the random number table. The western medicine group was treated with alendronate alone

the traditional Chinese medicine group was given traditional Chinese medicine prescription

and the observation group received alendronate combined with traditional Chinese medicine prescription. The bone mineral density( bone densitometer was used to detect the bone mineral density of L

2-4

Ward’s triangle and femoral neck respectively)

bone metabolism serum indicators [N-terminal osteocalcin（ N-MID）

bone alkalinity phosphatase（ BALP） and type Ⅰ procollagen N-terminal propeptide（ PⅠNP） ]of three groups were compared before and after treatment

and the visual analog scale（ VAS）

osteoporosis quality of life score（ OQOLS）

efficacy and adverse drug reaction were recorded. RESULTS: The total effective rate of the observation group was 96. 15%（ 50/52）

higher than 76. 92%（ 40/52） and 82. 69%（ 43/52） of the western medicine group and traditional Chinese medicine group

the difference was statistically significant（ P

<

0. 05）. Compared with before treatment

VAS score of three groups decreased and OQOLS score of three groups increased after treatment

and VAS score in the observation group was significantly lower than that in the western medicine group and traditional Chinese medicine group

and OQOLS score in the observation group was significantly higher than that in the Western medicine group and traditional Chinese medicine group

with statistically significant differences（ P

<

0. 05）. After treatment

the bone mineral density of L

2-4

Ward’s triangle and femoral neck of three groups were significantly higher than those before treatment

and the bone mineral density of L

2-4

Ward’s triangle and femoral neck of the observation group after treatment was significantly higher than those of the western medicine group and traditional Chinese medicine group

the differences were statistically significant（ P

<

0. 05）. After treatment

the levels of N-MID in three groups were lower than those before treatment

and the levels of BALP and PⅠNP were higher than those before treatment

the improvement of each indicator in the observation group was better than that in the western medicine group and traditional Chinese medicine group

the differences were statistically significant（ P

<

0. 05）. The incidences of adverse drug reactions in the western medicine group

traditional Chinese medicine group and observation group were respectively 9. 62%（ 5/52）

7. 69%（ 4/52） and 5. 77%（ 3/52）

the difference was not statistically significant（ P

>

0. 05）. CONCLUSIONS: The efficacy of traditional Chinese medicine prescription combined with alendronate in the treatment of postmenopausal osteoporosis is significant

which can effectively promote the growth of bone mineral density

improve the bone metabolism

reduce the pain degree and improve the quality of life of patients

with few adverse drug reactions.