OBJECTIVE: To probe into the effect of Qingwei Xiehuo recipe combined with tinidazole-assisted root canal filling on periodontal micro-ecological environment

gingival crevicular fluid interleukin（ IL）-1β and interleukin（ IL）-4

high-sensitivity C-reactive protein（ hs-CRP） levels and prognosis in patients with combined periodontalendodontic lesions. METHODS: Totally 100 patients with combined periodontal-endodontic lesions admitted into the Integrated Traditional Chinese and Western Medicine Hospital of Tongzhou District from Jan. 2019 to Apr. 2020 were selected and divided into observation group and control group via 1 ∶ 1 pairing randomization

with 50 cases in each group. The control group was given tinidazole-assisted root canal filling

while the observation group was given Qingwei Xiehuo recipe for 1 month combined with tinidazole-assisted root canal filling. The clinical efficacy

visual analogue scale（ VAS） of before treatment

2 weeks and 1 month after treatment

indicators of periodontal micro-ecological environment [dental plaque index（ PLI）

sulcus bleeding index（ SBI）

gingival index（ GI） and periodontal pocket depth（ PD） ]and oxidative stress response [malondialdehyde（ MDA） and superoxide dismutase（ SOD） ]

gingival crevicular fluid IL-1β

IL-4 and hs-CRP levels were compared between two groups; at 6-month follow-up visit after treatment

the prognoses of both groups were collected. RESULTS: The total effective rate of observation group at 1 month after treatment were 88. 0%（ 44/50）

which was significantly higher than that of the control group（ 62. 0%

31/50）

with statistically significant difference（ P<0. 05）. At 2 weeks and 1 month after treatment

the VAS score

PLI

SBI

GI and PD levels of observation group were significantly lower than those of the control group

and the gingival crevicular fluid IL-1β

IL4 and hs-CRP levels were significantly lower than those of the control group

with statistically significant differences（ P<0. 05）. The serum MDA levels of observation group at 2 weeks and 1 month after treatment were significantly lower than those of the control group

while the serum SOD levels were significantly higher

with statistically significant differences（ P < 0. 05）. After 6-month follow-up visit

the proportion of patients with periodontitis

tooth buckling pain and tooth loosening was lower in the observation group than in the control group

with statistically significant difference（ P < 0. 05）. CONCLUSIONS: The Qingwei Xiehuo recipe combined with tinidazole-assisted root canal filling in the treatment of combined periodontal-endodontic lesions can relieve oxidative damage and regulate periodontal micro-ecological environment by reduce inflammatory reaction

which is conducive to enhancing therapeutic effect

alleviating pain and promoting prognosis.