Systematic Review of Efficacy of Xuebijing Injection in Adjuvant Treatment of Severe Pneumonia and Its Effects on Cellular Immunity and Inflammatory Factors

HAN Tiantian; LI Danhua; LAI Yanni; LIU Xiaohong

doi:10.14009/j.issn.1672-2124.2021.08.017

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Systematic Review of Efficacy of Xuebijing Injection in Adjuvant Treatment of Severe Pneumonia and Its Effects on Cellular Immunity and Inflammatory Factors

更新时间：2022-10-08

- Systematic Review of Efficacy of Xuebijing Injection in Adjuvant Treatment of Severe Pneumonia and Its Effects on Cellular Immunity and Inflammatory Factors
- Vol. 21, Issue 8, Pages: 966-972(2021)
- 作者机构：
  
  1. 广州中医药大学第一临床医学院
  2. 广州中医药大学第一附属医院检验科
  3. 广州中医药大学第一附属医院呼吸科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.08.017
  CLC： R563.1
- Published：2021，
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HAN Tiantian, LI Danhua, LAI Yanni, et al. Systematic Review of Efficacy of Xuebijing Injection in Adjuvant Treatment of Severe Pneumonia and Its Effects on Cellular Immunity and Inflammatory Factors. [J]. 21(8):966-972(2021)
DOI：

HAN Tiantian, LI Danhua, LAI Yanni, et al. Systematic Review of Efficacy of Xuebijing Injection in Adjuvant Treatment of Severe Pneumonia and Its Effects on Cellular Immunity and Inflammatory Factors. [J]. 21(8):966-972(2021) DOI： 10.14009/j.issn.1672-2124.2021.08.017.

摘要

目的:系统评价血必净注射液辅助治疗重症肺炎的疗效及其对细胞免疫、炎症因子的影响

以期为临床实践提供更可靠的证据。方法:计算机检索PubMed、the Cochrane Library、Embase、中国知网、万方数据库、维普数据库和中国生物医学文献服务系统数据库中自建库至2020年3月发表的文献

查找有关血必净注射液辅助治疗重症肺炎的随机对照试验(研究组患者的干预措施为血必净注射液联合常规治疗

对照组患者为常规治疗)。由研究者筛选、评估后

纳入文献

使用Rev Man 5.3软件进行荟萃分析(Meta分析)。结果:最终纳入20项研究

涉及1 748例患者。Meta分析结果显示

研究组患者的有效率明显高于对照组(OR=3.75

95%CI=2.68～5.25

P<0.000 01)

研究组患者治疗后的白细胞介素6(SMD=-1.86

95%CI=-2.48～-1.24

P<0.000 01)、白细胞介素8(SMD=-1.09

95%CI=-1.51～-0.68

P<0.000 01)和肿瘤坏死因子α(SMD=-1.98

95%CI=-2.62～-1.34

P<0.000 01)水平明显低于对照组

研究组患者治疗后的白细胞介素10(SMD=0.31

95%CI=0.06～0.55

P=0.01)、CD3+(MD=9.05

95%CI=6.17～11.93

P<0.000 01)、CD4+(MD=9.20

95%CI=3.55～14.86

P=0.001)和CD4+/CD8+(MD=0.52

95%CI=0.31～0.73

P<0.000 01)水平明显高于对照组

上述差异均有统计学意义。结论:与单纯使用常规治疗比较

联合应用血必净注射液辅助治疗重症肺炎有较好的抗炎及调节免疫的效果。

Abstract

OBJECTIVE: To systematically evaluate the efficacy of Xuebijing injection in adjuvant treatment of severe pneumonia and its effects on cellular immunity and inflammatory factors

so as to provide more reliable evidence for clinical practice.METHODS: PubMed

the Cochrane Library

Embase

CNKI

Wanfang database

VIP database and CBM were retrieved to collect the randomized controlled trial of Xuebijing injection in adjuvant treatment of severe pneumonia and its effects on cellular immunity and inflammatory factors（ the intervention measures in the study group were Xuebijing injection combined with routine treatment

while those in the control group were routine treatment）

the retrieval time was from the establishment of the database to Mar.2020. After being screened and evaluated by the investigator

the literature was included

and RevMan 5. 3 software was used for Meta-analysis.RESULTS: Totally 20 literature were collected

including 1 748 patients. Meta-analysis results showed that the effective rate in the study group was significantly higher than that in the control group（ OR = 3. 75

95% CI = 2. 68-5. 25

P < 0. 000 01）

interleukin 6（ SMD =-1. 86

95% CI =-2. 48--1. 24

P < 0. 000 01）

interleukin 8（ SMD =-1. 09

95% CI =-1. 51--0. 68

P < 0. 000 01） and tumor necrosis factor α（ SMD =-1. 98

95% CI =-2. 62--1. 34

P < 0. 000 01） were significantly lower than those in the control group

interleukin 10（ SMD = 0. 31

95%CI = 0. 06-0. 55

P = 0. 01）、CD3+（ MD = 9. 05

95% CI = 6. 17-11. 93

P < 0. 000 01）

CD4+（ MD = 9. 20

95% CI = 3. 55-14. 86

P = 0. 001） and CD4+/CD8+（ MD=0. 52

95%CI=0. 31-0. 73

P<0. 000 01） levels were significantly higher than those of the control group

with statistically significant differences. CONCLUSIONS: Compared with the conventional treatment alone

Xuebijing injection in adjuvant treatment of severe pneumonia has better anti-inflammatory and immune-regulating effects.

关键词

血必净注射液重症肺炎炎症因子免疫Meta分析

Keywords

Xuebijing injectionSevere pneumoniaInflammatory factorsImmunityMeta-analysis

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