OBJECTIVE: To probe into the effect of Dangua Humai oral liquid on vascular endothelial function and oxidative stress indicators in patients with type 2 diabetes mellitus（ T2 DM） complicated with non-alcoholic fatty liver disease（ NAFLD） under the guidance of co-treatment of phlegm and stasis. METHODS: Totally 92 patients with T2 DM complicated with NAFLD admitted into the Affiliated People ’ s Hospital of Fujian University of Traditional Chinese Medicine from Jan. 2018 to Jul. 2020 were selected and divided into control group（ 46 cases） and observation group（ 46 cases） according to the admission sequences. The control group was given conventional therapy

while the observation group was given Dangua Humai oral liquid based on the control group under the guidance of co-treatment of phlegm and stasis

both groups were treated for 3 months. The clinical efficacy

blood glucose [fasting blood glucose（ FBG）

2 h postprandial blood glucose（ 2 hBG） and glycosylated hemoglobin（ Hb Alc） ] levels

blood lipid [total cholesterol（ TC）

triglyceride（ TG）

high-density lipoprotein（ HDL） and low-density lipoprotein（ LDL） ] levels

liver function indicators [alanine aminotransferase（ ALT）

aspartate transaminase（ AST） and γ-glutamyltransferase（ GGT） ]

vascular endothelial function indicators [vascular endothelial growth factor（ VEGF）

endothelin（ ET-1） ]and oxidative stress indicators [malondialdehyde（ MDA）

superoxide dismutase（ SOD） ] levels were compared between two groups before and after treatment. RESULTS: The total effective rate of observation group was 89. 13%（ 41/46）

which was significantly higher than that of the control group（ 71. 74%

33/46）

with statistically significant difference（ P<0. 05）. After treatment

the FBG

2 h BG

Hb Alc

TC

TG

LDL

ALT

AST

GGT

ET-1 and MDA levels of both groups had been significantly decreased

while the HDL

VEGF and SOD levels were significantly increased

with statistically significant differences（ P < 0. 05）; there were no statistical significance in differences in FBG

HbAlc

ALT

AST and GGT levels between observation group and control group（ P>0. 05）

the2 hBG

TC

TG

LDL

ET-1 and MDA levels of observation group were significantly lower than those of the control group

while the HDL

VEGF and SOD levels were significantly higher than those of the control group

with statistically significant differences（ P < 0. 05）. CONCLUSIONS: Under the guidance of co-treatment of phlegm and stasis

Dangua Humai oral liquid can better regulate blood lipid and blood glucose metabolism in patients with T2 DM complicated with NAFLD

improve their vascular endothelial function

reduce oxidative stress and promote therapeutic effect

without significant adverse drug effects.