Efficacy of Dexamethasone Combined with Metronidazole in the Treatment of Ductal Ectasia of Breast and Its Effect on IL-10 and IL-17

YANG Hailing; ZHU Na; LI Tianxiu; MA Jia; WANG Jingfang

doi:10.14009/j.issn.1672-2124.2021.08.004

您当前的位置：

首页 >

文章列表页 >

Efficacy of Dexamethasone Combined with Metronidazole in the Treatment of Ductal Ectasia of Breast and Its Effect on IL-10 and IL-17

更新时间：2022-10-08

- Efficacy of Dexamethasone Combined with Metronidazole in the Treatment of Ductal Ectasia of Breast and Its Effect on IL-10 and IL-17
- Vol. 21, Issue 8, Pages: 915-917(2021)
- 作者机构：
  
  1. 西北大学附属医院·西安市第三医院药剂科
  2. 铜川市耀州区人民医院药剂科
  3. 解放军第四五一医院妇产科
  4. 解放军第四五一医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.08.004
  CLC： R655.8
- Published：2021，
扫描看全文
YANG Hailing, ZHU Na, LI Tianxiu, et al. Efficacy of Dexamethasone Combined with Metronidazole in the Treatment of Ductal Ectasia of Breast and Its Effect on IL-10 and IL-17. [J]. 21(8):915-917(2021)
DOI：

YANG Hailing, ZHU Na, LI Tianxiu, et al. Efficacy of Dexamethasone Combined with Metronidazole in the Treatment of Ductal Ectasia of Breast and Its Effect on IL-10 and IL-17. [J]. 21(8):915-917(2021) DOI： 10.14009/j.issn.1672-2124.2021.08.004.

摘要

目的:探讨地塞米松联合甲硝唑治疗乳腺导管扩张症的疗效及对血清白细胞介素10（IL-10）、白细胞介素17（IL-17）的影响。方法:选取2019—2020年西安市第三医院收治的乳腺导管扩张症患者232例

根据随机数字表法分为联合组（地塞米松联合甲硝唑治疗

116例）和单药组（甲硝唑单药治疗

116例）。比较联合组与单药组患者的临床疗效

比较治疗前后联合组与单药组患者的IL-10、IL-17水平及治疗后较治疗前变化值（ΔIL-10、ΔIL-17）。结果:联合组患者的总有效率较单药组显著升高[92.2%（107/116）与76.7%（89/116）比较

=10.653

P=0.001]。治疗后

联合组患者的IL-10（t=2.364

P=0.020）、ΔIL-10（t=3.641

0.001）较单药组显著升高

IL-17（t=3.821

0.001）、ΔIL-17（t=2.416

P=0.017）较单药组显著降低

差异均有统计学意义。结论:地塞米松联合甲硝唑治疗可以显著提高乳腺导管扩张症患者的临床疗效。

Abstract

OBJECTIVE: To probe into the efficacy of dexamethasone combined with metronidazole in the treatment of ductal ectasia of breast and its effect on interleukin-10（ IL-10） and interleukin-17（ IL-17）. METHODS: Totally 232 patients with ductal ectasia of breast admitted into the Third Hospital of Xi’an from 2019 to 2020 were selected and divided into combined treatment group（ given dexamethasone combined with metronidazole for treatment

116 cases） and single drug group（ treated with metronidazole alone

116 cases） via random number table. The clinical efficacy

IL-10 and IL-17 levels

the change values（ ΔIL-10 and ΔIL-17） compared with those before and after treatment in patients in combined treatment group and single drug group were compared. RESULTS: The total effective rate of combined treatment group was significantly higher than that of the single drug group[92. 2%（ 107/116） compared with 76. 7%（ 89/116）

= 10. 653

P = 0. 001]. After treatment

the IL-10（ t = 2. 364

P = 0. 020） and ΔIL-10（ t = 3. 641

0. 001）levels of combined treatment group were significantly higher than those of the single drug group

while the IL-17（ t =3. 821

0. 001） and ΔIL-17（ t = 2. 416

P = 0. 017） levels were significantly lower than the single-agent group

with statistically significant differences. CONCLUSIONS: dexamethasone combined with metronidazole can significantly improve the clinical efficacy in the treatment of ductal ectasia of breast.

关键词

乳腺导管扩张症地塞米松甲硝唑疗效

Keywords

Ductal ectasia of breastDexamethasoneMetronidazoleEfficacy

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Blood Trough Concentration Monitoring and Efficacy of Vancomycin in the Treatment of Methicillin-Resistant Staphylococcus aureus Infection

Efficacy of Huaiqihuang Granules in the Adjuvant Treatment of Lupus Nephritis and Its Effects on Serum Ferritin

Prognosis and Safety of Programmed Death 1 Inhibitors in First-Line Treatment of Advanced Non-Small Cell Lung Cancer

Efficacy and Safety of Apatinib Mesylate Combined with Etoposide in the Treatment of Platinum-Resistant Recurrent Ovarian Cancer

Pharmacodynamic Analysis of Levetiracetam in the Treatment of Epilepsy in Children

Related Author

LIU Yunning

LI Xiaofeng

TANG Jianhua

JIANG Aiwen

CHU Mingjuan

ZHANG Heming

WANG Jie

LI Yuan

Related Institution

Dept.of Microbiology, the First Affiliated Hospital of Hebei North University

Dept.of Pharmacy, the First Affiliated Hospital of Hebei North University

Dept.of Integrated Chinese and Western Medicine, Liyuan Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology

Dept. of Oncology, Huangshan People’s Hospital

Dept. of Gynaecology and Obstetrics,the Sixth Medical Center of PLA General Hospital

⁰