OBJECTIVE: To investigate the detection status of carbapenem-resistant Enterobacteriaceae（ CRE） in emergency intensive care unit（ EICU）

and to explore the effect of comprehensive intervention measures for prevention and control of CRE in EICU

so as to provide reference for prevention and control of nosocomial infection. METHODS:In 2017 and 2018

the environment and surface of the EICU

the medical personnel and inpatients were sampled by the professional staff of a grade Ⅲ

level A hospital（ hereinafter referred to as "the hospital"） to screen for CRE.From 2018 to 2020

the effectiveness of the intervention were evaluated through strict implementation of cluster infection control measures such as hand hygiene

isolation measures

cleaning and disinfection and active monitoring.RESULTS: In 2017

the carbapenem-resistant Escherichia coli strain with multiple carbapenem resistance genes（ blaIMP-4

blaNDM-1 and blaVIM-2） was detected on the surface of the return air vent in EICU. From 2018 to 2020

the incidence of nosocomial infection in EICU decreased year by year

and no nosocomial infection caused by CRE was found. CONCLUSIONS: Comprehensive intervention measures can effectively reduce the colonization of CRE in the environment and on the surface of objects

and reduce the cross-transmission of CRE in the ward.