OBJECTIVE: To investigate the basic situation of acute kidney injury（ AKI） induced by piperacillin and tazobactam in elderly patients

and explore the risk factors that may increase nephrotoxicity. METHODS: A singlecenter and retrospective cohort study on elderly patients hospitalized with infection who were given piperacillin and tazobactam intravenous drip treatment in a Grade Ⅲ Level A general hospital from 2019 to 2020 was screened and collected. Statistical analysis was conducted on the data and main outcomes of tests such as creatinine before and after medication

so that the risk factors associated with AKI induced by piperacillin and tazobactam in the elderly were finally derived. RESULTS: A total of 2 669 elderly patients were collected

of whom 141 cases developed AKI

with an incidence of 5. 28%

with grade one took the lead. Results of univariate analysis showed that 7 factors were associated with AKI（ P < 0. 05）. After logistic regression analysis

it was cleared that treatment course

drug combined

acid-base imbalance

anemia and rationality of medication were the main risk factors of the occurrence of AKI after using piperacillin and tazobactam. CONCLUSIONS: Medical staff should understand the risk factors associated with the occurrence of AKI in elderly patients

take appropriate measures to enhance the monitoring of the medication process and rationally.