OBJECTIVE: To explore the pathogen distribution and drug sensitivity test results of craniocerebral injury complicated with pulmonary infection

and probe into the therapeutic effect of high pressure oxygen combined with bronchoalveolar lavage in the treatment of craniocerebral injury complicated with pulmonary infection.METHODS: Totally 96 patients with severe craniocerebral injury complicated with pulmonary infection admitted into Pinggu Hospital of Beijing Friendship Hospital Affiliated to Capital Medical University from Jan. 2017 to Jun. 2019 were selected and analyzed in terms of pathogen distribution and drug sensitivity. These patients were divided into research group and control group via random number table

with 48 cases in each group. The control group was given bronchoalveolar lavage for treatment

while the research group was given high pressure oxygen combined with bronchoalveolar lavage for treatment

so that the therapeutic effect was compared between two groups. RESULTS:Totally 215 strains of pathogenic bacteria were isolated

of which 141 strains were gram-negative bacteria（ 65. 58%）

66 strains were gram-positive bacteria（ 30. 70%）

8 strains were fungus（ 3. 72%）. The drug sensitivity test indicated that the major gram-negative bacteria were relatively more sensitive to cefoxitin/sulbactam and imipenem

while less sensitive to piperacillin

cefoperazone and cefotaxime; the major gram-positive bacteria were relatively more sensitive to compound sulfamethoxazole tablets and vancomycin

while less sensitive to penicillin

azithromycin

ciprofloxacin

clindamycin and cefazolin. The arterial partial pressure of oxygen（ PaO2） level and Glasgow coma score（ GCS） of patients in both groups were significantly higher after treatment

and the PaO2 level and GCS score of patients in the research group were significantly higher than those in the control group

with statistically significant differences（ P <0. 05）. The total effective rate of the research group was 95. 83%（ 46/48）

which was significantly higher than that of the control group（ 81. 25%

39/48）

with statistically significant difference（ P < 0. 05）. CONCLUSIONS: The main pathogenic bacteria of craniocerebral injury complicated with pulmonary infection are gram-negative bacteria

the drug sensitivity test can guide the rational application of antibiotics; the application of high pressure oxygen combined with bronchoalveolar lavage can effectively improve the therapeutic efficacy in the treatment of patients with craniocerebral injury complicated with pulmonary infection.