Research Progress of Protect Effect of Schisandra Chinensis on Liver Injury and Its Molecular Mechanism

FU Ran; LI Ri; WANG Xiaonan; CUI Yanjun; FAN Liju; DONG Zhanjun

doi:10.14009/j.issn.1672-2124.2021.06.028

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Research Progress of Protect Effect of Schisandra Chinensis on Liver Injury and Its Molecular Mechanism

更新时间：2022-10-08

- Research Progress of Protect Effect of Schisandra Chinensis on Liver Injury and Its Molecular Mechanism
- Vol. 21, Issue 6, Pages: 761-763(2021)
- 作者机构：
  
  1. 河北医科大学研究生学院
  2. 河北省人民医院药学部
  3. 华北理工大学研究生学院
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.06.028
  CLC： R285
- Published：2021，
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FU Ran, LI Ri, WANG Xiaonan, et al. Research Progress of Protect Effect of Schisandra Chinensis on Liver Injury and Its Molecular Mechanism. [J]. 21(6):761-763(2021)
DOI：

FU Ran, LI Ri, WANG Xiaonan, et al. Research Progress of Protect Effect of Schisandra Chinensis on Liver Injury and Its Molecular Mechanism. [J]. 21(6):761-763(2021) DOI： 10.14009/j.issn.1672-2124.2021.06.028.

摘要

五味子是传统的保肝药物

其不仅可降低氨基转移酶水平

还具有抗氧化、抗炎和抑制细胞凋亡等多种药理作用

被广泛应用于各种类型的肝损伤

其分子机制主要与Nrf2信号通路、孕烷X受体、p53/p21信号通路、核因子κB信号通路及丝裂原活化蛋白激酶信号通路有关。本文通过查阅文献

对五味子保肝作用的分子机制进行总结

以期为五味子的合理应用提供参考。

Abstract

Schisandra chinensis is a traditional hepatoprotective drug

which can not only reduces aminotransferase levels

but also has various pharmacological effects such as antioxidant

anti-inflammatory and apoptosis inhibition

and is widely used in treatment of various types of liver injury

its molecular mechanisms are mainly related to the Nrf2 signaling pathway

pregnane X receptor

p53/p21 signaling pathway

nuclear factor κB signaling pathway and mitogen-activated protein kinase signaling pathway. This paper has reviewed related literature to summarize the molecular mechanisms of hepatoprotective effects of schisandra chinensis

so as to provide references for the rational application of schisandra chinensis.

关键词

五味子肝损伤作用机制研究进展

Keywords

Schisandra chinensisLiver injuryMechanism of actionResearch progress

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Related Author

CAO Junling

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Related Institution

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