OBJECTIVE: To probe into the general rule and characteristics of adverse drug reaction（ ADR）induced by cefoselis

so as to provide references for clinical medication. METHODS: Reports related to ADR induced by cefoselis published in domestic and foreign medical journals from CNKI

VIP

Wanfang and PubMed from basebuilding to Jan. 2020 were retrieved and conducted statistical analysis on the data. RESULTS: Totally 20 controlled clinical studies and non-comparative case reports were retrieved in the same period

a total of 1 218 cases of cefoselis used

121 cases of ADR were reported

with the incidence of ADR was 9. 93%

of which the incidence of hepatobiliary system reactions was the highest（ 3. 69%

45 cases）

followed by gastrointestinal system reactions（ 2. 38%

29 cases）. A total of 8 case reports of ADR caused by cefoselis were collected

with 11 valid cases

of which 9 cases（ 81. 82%） were male and 2 cases（ 18. 18%） were female

with obviously more males than females;the age ranged from 35 to 87 years

mainly concentrated in people aged > 60 years

especially the elderly patients aged > 80 years; the ADR were mainly manifested as central nervous system symptoms such as disturbance of consciousness; the number of ADR cases appeared in 2-3 d of drug administration was the highest

with 8 cases（ 72. 73%）. CONCLUSIONS: The clinical application of cefoselis should strictly grasp its indications and strengthen medication monitoring to ensure safe

effective and economic medication.