OBJECTIVE: To probe into the effects of pharmaceutical service on the correct use

compliance and efficacy of tiotropium bromide powder spray in patients with chronic obstructive pulmonary disease（ COPD）.METHODS: Totally 105 COPD patients admitted into the 983 th Hospital of Joint Logistics Support Forces of PLA from Feb. 2018 to Aug. 2019 were selected as subjects

according to the order of admission and treatment

the patients were divided into two groups via random number table

52 patients in control group did not receive any intervention

while the 53 patients in research group received pharmaceutical service intervention. The correct rate of use and compliance of tiotropium bromide powder spray were compared between two groups

the efficacy

pulmonary function and modified British medical research council（ m MRC） rating were compared between two groups in 12-month follow-up visit.RESULTS:（ 1） At 6-month and 12-month follow-up visit

the correct rate of use

score of Morisky medication adherence scale-8（ MMAS-8）

forced expiratory volume in 1 s（ FEV1）

the ratio of FEV1 and forced vital capacity（ FVC） of research group were significantly higher those at 1 month of enrollment

and the m MRC ratings were significantly lower than that at 1 month of enrollment

with statistically significant differences（ P < 0. 05）.（ 2） At12-month follow-up visit

the correct rate of tiotropium bromide powder spray use

MMAS-8 score

FEV1 and FEV1/FVC of the research group were significantly higher than those at 6-month follow-up visit

and the m MRC rating was significantly lower than that at 6-month follow-up visit

with statistically significant differences（ P < 0. 05）.（ 3） At6-month and 12-month follow-up visit

the correct rate of tiotropium bromide powder spray use

MMAS-8 score

FEV1 and FEV1/FVC of the research group were significantly higher than those of the control group

and the m MRC rating was significantly lower than that of the control group

with statistically significant differences（ P < 0. 05）.（ 4） At12-month follow-up visit

the overall effective rate of research group was significantly higher than that of the control group

with statistically significant differences（ P < 0. 05）. CONCLUSIONS: Pharmaceutical service can effectively promote the correct use

compliance and efficacy of tiotropium bromide powder spray in COPD patients

improve patients’ pulmonary function and relieve dyspnea.