Analysis of Influencing Factors of Drug Concentration/Dose Ratio of Sertraline in Patients with Depression Based on Therapeutic Drug Monitoring

TAN Yaqian; CHEN Ziqi; LIU Shujing; LI Xiaolin; XIAO Tao; HUANG Shanqing; WEN Yuguan; SHANG Dewei

doi:10.14009/j.issn.1672-2124.2021.06.014

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Analysis of Influencing Factors of Drug Concentration/Dose Ratio of Sertraline in Patients with Depression Based on Therapeutic Drug Monitoring

更新时间：2022-10-08

- Analysis of Influencing Factors of Drug Concentration/Dose Ratio of Sertraline in Patients with Depression Based on Therapeutic Drug Monitoring
- Vol. 21, Issue 6, Pages: 698-700(2021)
- 作者机构：
  
  1. 广州医科大学附属脑科医院药学部
  2. 广州医科大学药学院
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.06.014
  CLC： R969
- Published：2021，
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TAN Yaqian, CHEN Ziqi, LIU Shujing, et al. Analysis of Influencing Factors of Drug Concentration/Dose Ratio of Sertraline in Patients with Depression Based on Therapeutic Drug Monitoring. [J]. 21(6):698-700(2021)
DOI：

TAN Yaqian, CHEN Ziqi, LIU Shujing, et al. Analysis of Influencing Factors of Drug Concentration/Dose Ratio of Sertraline in Patients with Depression Based on Therapeutic Drug Monitoring. [J]. 21(6):698-700(2021) DOI： 10.14009/j.issn.1672-2124.2021.06.014.

摘要

目的:探讨抑郁症患者服用舍曲林后血药浓度/剂量比(C/D)的影响因素

为舍曲林的临床个体化用药提供参考。方法:回顾性分析2019—2020年广州医科大学附属脑科医院收治的373例进行过舍曲林治疗药物监测的抑郁症患者的529份血药浓度监测数据

将性别、年龄、体重指数(BMI)、给药频次以及联合用药等资料录入表格

采用SPSS 23.0软件对以上数据进行统计分析。结果:BMI、给药频次会显著影响舍曲林的C/D(P <0.05);联合应用奥氮平组患者的舍曲林的C/D显著高于未使用奥氮平组(P <0.05);联合应用锂盐组患者的舍曲林的C/D显著高于未使用锂盐组(P <0.01)

上述差异均有统计学意义。在多重线性回归分析模型中

剂量、给药频次以及联合应用奥氮平或锂盐对舍曲林血药浓度的影响具有统计学意义。结论:舍曲林血药浓度的影响因素复杂

与服药剂量有较大关系。本研究结果提示

联合应用奥氮平或锂盐可能需要调整舍曲林的剂量。

Abstract

OBJECTIVE: To explore the influencing factors of drug concentration/dose ratio（ C/D） in patients with depression after taking sertraline

so as to provide reference for the clinical individualized medication of sertraline.METHODS: Retrospective analysis was performed on 529 drug concentration monitoring data from 373 patients with depression who received sertraline therapy monitoring in the Affiliated Brain Hospital of Guangzhou Medical University from 2019 to 2020. Data such as gender

age

body mass index（ BMI）

frequency of administration and drug combination were entered into the table. SPSS 23. 0 software was used for statistical analysis of the above data.RESULTS: BMI and administration frequency had significant effects on C/D of sertraline（ P < 0. 05）. The C/D of sertraline in the combined olanzapine group was significantly higher than that in the non-olanzapine group（ P < 0. 05）.The C/D of sertraline in the combined lithium group was significantly higher than that in the non-lithium group（ P <0. 01）

the differences were statistically significant. In the multiple linear regression analysis model

the effects of dose

frequency of administration and drug combination of olanzapine or lithium on blood concentration of sertraline were statistically significant. CONCLUSIONS: The influencing factors of blood concentration of sertraline are complex and have a great relationship with the dosage. The results of this study suggest that the drug combination of olanzapine or lithium may require dose adjustment of sertraline.

关键词

舍曲林治疗药物监测剂量校正浓度

Keywords

SertralineTherapeutic drug monitoringDose-Corrected concentration

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